Congenital Heart Defects Clinical Trial
Official title:
National Natural Science Foundation of China
The purpose of this study is to determine whether electroacupuncture preconditioning would provide protection against myocardial Ischemic-Reperfusion injury and systemic inflammation in children undergoing CPB for repair of congenital heart defects.
2-12 years old children undergoing repair of congenital heart defects were included, except for those with server pulmonary arterial hypertension, chromosomal defects, airway and parenchymal lung disease, immunodeficiency, or blood disorders were excluded. Children were equal randomized to EAPC(electroacupuncture preconditioning)or control group. Electroacupuncture was administered on the bilateral P6 acupoint after anesthesia induction, but prior to surgery in EAPC group. Control patients underwent sham placement of the electrode the arm without stimulation. The duration of cardiopulmonary bypass and aortic cross-clamp time was recorded. Myocardial injury was assessed by cardiac heart-type fatty acid-binding protein (HFAP) and cardiac troponin I (cTnI>0.40 ng/mL). 8-isoprostane , C-reactive protein, cytokines were measured pre- and postoperatively. ;
Observational Model: Case Control, Time Perspective: Retrospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01671566 -
Interval Training in Adults With Congenital Heart Disease a Randomized Trial
|
N/A | |
| Recruiting |
NCT01421030 -
Outcomes in Patients and Their Closest Relatives Treated for Congenital Heart Disease With Catheter Based or Surgical Techniques
|
Phase 0 | |
| Completed |
NCT01567579 -
An Evaluation of Routine Developmental Follow-Up in Infants and Children With Congenital Heart Disease
|
||
| Withdrawn |
NCT00981591 -
Inhaled Iloprost as an Adjunct to Inhaled Nitric Oxide in Pediatric Critical Care Patients
|
Phase 1/Phase 2 | |
| Terminated |
NCT00208676 -
Using Tissue Doppler/Synchronization to Determine Heart Function in Children With Congenital Heart Disease
|
N/A | |
| Completed |
NCT01941576 -
Effects of rhBNP in Pediatrics After Corrective Repair of Tetralogy Of Fallot
|
N/A | |
| Completed |
NCT01475357 -
Intestinal Function in Neonates With Complex Congenital Heart Disease
|
N/A | |
| Completed |
NCT00397514 -
Assessing the Hemodynamic Benefits of Cardiac Resynchronization Therapy in Children Following Open-Heart Surgery
|
N/A | |
| Completed |
NCT01201486 -
Use of Color Doppler in Routine Examination of Fetal Heart in Second Trimester
|
N/A | |
| Completed |
NCT02232399 -
Is Levosimendan Superior to Milrinone Regarding Acute Kidney Injury After Cardiac Surgery for Congenital Heart Disease?
|
Phase 2 | |
| Completed |
NCT05191654 -
Investigation of Cardiopulmonary Parameters, Motor Development and Muscle Strength in DS With and Without CHD
|
||
| Recruiting |
NCT06267859 -
Development of Methods for Effective Treatment and Improvement of Common Somatic Diseases in Children
|
Early Phase 1 | |
| Completed |
NCT02320669 -
Phase 3 Triiodothyronine Supplementation for Infants After Cardiopulmonary Bypass
|
Phase 3 | |
| Completed |
NCT01489475 -
Plasma Angiopoietin Levels in Children Following Cardiopulmonary Bypass
|
N/A | |
| Withdrawn |
NCT00579358 -
Molecular Basis of Congenital Heart Defects
|
||
| Recruiting |
NCT01196182 -
Congenital Heart Disease GEnetic NEtwork Study (CHD GENES)
|
||
| Recruiting |
NCT03822442 -
MRI to Predict Rejection and Failure in Transplant and Cardiomyopathy Patients
|
||
| Recruiting |
NCT04382573 -
Better Delineation of CDK13 Related Phenotype and Epigenetic Signature.
|
||
| Completed |
NCT00450684 -
Cardiac Resynchronization Therapy in Congenital Heart Defects
|
Phase 2/Phase 3 | |
| Terminated |
NCT00208754 -
Heart Failure in Adult Patients With a History of Congenital Heart Disease
|
N/A |