Effects of Bright Light Therapy in Mild Traumatic Brain Injury

Status Completed

Clinical Trial Summary

Mild traumatic brain injuries (mTBI) or "concussions" are an increasingly prevalent injury in our society. Patients with post-concussion syndrome have been shown to have deficits on tests of short term memory, divided attention, multi-tasking, information processing speed, and reaction time, as well as alteration in mood and emotional functioning. Many patients have other vague complaints including fatigue, dizziness, irritability, sleep disturbances, and chronic headaches. Furthermore, sleep disruption of one of the most common complaints in patients suffering from traumatic brain injuries, with as many as 40 to 65% of patients with mTBI complaining of insomnia. Sleep problems in these patients are associated with poorer outcome, while resolution of the sleep disturbance is associated with improvement in cognitive functioning.

Despite recent evidence of the correlation between sleep quality and recovery from traumatic brain injury, and the well-established role of sleep in neural plasticity and neurogenesis, there have been virtually no direct studies of the causal effects of sleep on recovery following mTBI. However, it is quite likely that sleep plays a critical role in recovery following brain injury.

A particularly promising non-pharmacologic approach that shows potential in improving/modifying abnormalities of the circadian rhythm and sleep-wake schedule is bright light therapy. For the proposed investigation, we hypothesize that bright light therapy may be helpful in improving the sleep of patients with a recent history of mTBI and may also have other mood elevating effects, both of which should promote positive treatment outcome in these individuals. Bright light therapy may increase the likelihood that they will recover more quickly, benefit more extensively from other forms of therapy, and build emotional and cognitive resilience.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01747811
Study type	Interventional
Source	University of Arizona
Contact
Status	Completed
Phase	N/A
Start date	December 2010
Completion date	December 2013

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05849064` - Concussion Treatment in Older Adults	N/A
Terminated	`NCT04586179` - A Comparison Between Cardiovascular Exercise Modes Following Sport Related Concussion	N/A
Not yet recruiting	`NCT05943561` - Biomarkers in Concussion
Completed	`NCT02721537` - Use of 31P MRS to Assess Brain NAD+ in Healthy Current and Former Collegiate Athletes	N/A
Completed	`NCT03236389` - Brain Dynamics in Response to Jugular Vein Compression	N/A
Completed	`NCT01832714` - Assessment of Oculomotor, Vestibular and Reaction Time Response Following a Concussive Event
Completed	`NCT04560400` - Reverse King-Devick Test and History of Multiple Concussions	N/A
Completed	`NCT03678077` - Trends in Cohabitation Status, Academic Achievement and Socio-economic Indicators After Mild Traumatic Brain Injury
Recruiting	`NCT05262361` - Persistent Post-Concussion Symptoms With Convergence Insufficiency	N/A
Recruiting	`NCT05105802` - Mindfulness-Based Intervention for Mild Traumatic Brain Injury	N/A
Terminated	`NCT03123822` - Spectacles Lens in Concussed Kids	N/A
Completed	`NCT04641832` - The Combined Effect of Chronic Cannabis Use and Subconcussive Head Impacts on Brain Health	N/A
Completed	`NCT04074486` - Evaluation and Validation of a Multimodal Brain Function Biomarker With NPC
Withdrawn	`NCT04578743` - Exercise as Concussion Therapy Trial- 2	Phase 2
Completed	`NCT03170856` - The Effects of a Sub-maximal Exercise Program on Adolescents Who Sustained a Concussion	N/A
Completed	`NCT03671083` - Validation of Brain Function Assessment Algorithm for mTBI/Concussion
Completed	`NCT05069948` - Delivery of Digital Cognitive Behavioural Therapy Following Concussion	N/A
Recruiting	`NCT03889483` - Neurophysiological Measurements Using the NeuroCatch™ Platform in Pediatric Concussion	N/A
Withdrawn	`NCT02959294` - Use of Adipose-Derived Stem/Stromal Cells in Concussion and Traumatic Brain Injuries	Early Phase 1
Recruiting	`NCT06093295` - Non-invasive Brain Stimulation and Injury Risk Biomechanics	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.