Complex Regional Pain Syndromes Clinical Trial
Official title:
Low Dose Administration of Delta9-Tetrahydrocannabinol for the Prevention of Hyperalgesia and Chronic Pain in Patients With Acute Complex Regional Pain Syndrome (CRPS) of the Upper Limb
The purpose of this study is to determine whether application of low dose Delta9-Tetrahydrocannabinol can prevent the development of chronic pain in patients with acute CRPS.
Recent animal data suggest that the endocannabinoid system is a promising target in the
prevention of chronic pain. It has been shown that the endocannabinoid system modifies
excitatory and inhibitory currents in structures involved in the development of chronic pain
such as the amygdala.
CRPS is a neuropathic pain condition, which is known to become chronic in a significant
percentage. The study compares the effect of low dose Delta9-Tetrahydrocannabinol (90 days)
and placebo in acute CRPS. All patients will receive a standard treatment consisting of drug
therapy and physiotherapy.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double-Blind, Primary Purpose: Prevention
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