Community-Acquired Pneumonia Clinical Trial
Official title:
Effect of Simvastatin on Pneumonia Prognosis in Elderly Patients: A Study of Immunological, Inflammatory, and Coagulation Responses in Relation to Reduce Mortality During Hospitalization
The objective is to assess the effect of simvastatin on immunology, inflammatory, and
coagulation responses, and mortality in elderly with pneumonia based. The primary outcome is
mortality event.
The hypothesis of this study is that simvastatin therapy will reduce mortality in elderly
with pneumonia.
Elderly patients diagnosed with pneumonia after getting information and signing informed
consent will be included in this trial. Simvastatin 20 mg will be administered to
intervention group, while control group will receive placebo. Both groups will receive drugs
(or placebo) for 30 days.
Baseline data will be collected within 24 hours after admission. Then the subject will be
followed up for 30 days. At the 7th day, patients will be underwent several laboratory
tests, i.e. serum TNF-α (Tumor Necrosis Factor alpha), IFN-ϒ Interferon gamma), CRP
(C-Reactive Protein), and PAI-1 (Plasminogen Activator Inhibitor-1). Death from all causes
until 30 days will be recorded.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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