Early Biomarkers of Tumor Response in High Dose Hypofractionated

Status Terminated

Clinical Trial Summary

This study will follow-up immune cell populations, secreted factors and released nanovesicles in the blood before, during and after high dose radiation therapy which should give new information of the efficacy of the hypofractionated high dose radiation therapy and a rationale for adjuvant immunotherapy.

Clinical Trial Description

- Patient information and collection of a signed informed consent form

- Clinical data collection

- Blood samples of 35 mL:

1. after registration, prior to the first fraction of radiotherapy

2. within 15 minutes after the administration of the 1st, the 2nd and the 3rd radiotherapy sessions

3. one week, 3 months, 6 months, 9 months and 12 months after the last radiotherapy session

- Storage of the blood samples at ambient temperature

- Transportation of the samples to the Institute of Biology of Lille (IBL) - CNRS UMR8161 for analysis

- Destruction of the samples at the end of the analysis ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02439008
Study type	Interventional
Source	Centre Oscar Lambret
Contact
Status	Terminated
Phase	N/A
Start date	September 16, 2015
Completion date	March 18, 2019

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Early Biomarkers of Tumor Response in High Dose Hypofractionated Radiotherapy Word Package 3 : Immune Response

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms