A Trial of Omeprazole and Low Dose Aspirin to Identify Colorectal Biomarkers of Preventive Efficacy

Colorectal Neoplasia Clinical Trial

Official title:

An Early Phase 1 Trial of Omeprazole and Low Dose Aspirin to Identify Colorectal Biomarkers of Preventive Efficacy: The Omeprazole and Aspirin Polyp Prevention Study

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06378398
• Other study ID #: UMCC 2023.037
• Secondary ID: HUM00247729UMI23
• Status: Not yet recruiting
• Phase: Early Phase 1
• Start date: May 2024
• Est. completion date: August 2024

Study information

• Verified date: April 2024
• Source: University of Michigan Rogel Cancer Center
• Contact: Kirsten Tuck
• Phone: 734-763-1141
• Email: KLtuck[@]med.umich.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This trial will obtain biomarker data on the possible preventive effects of omeprazole and low-dose aspirin in colorectal tissue. Persons who have had 5 or more adenomas, 5 or more serrated polyps, or an incompletely removed adenoma or serrated polyp in the colon or rectum are potentially eligible. Before participating in the study, study staff will explain the study and review the consent form. If you are interested and provide consent, study staff will then confirm your eligibility. Once enrolled, participants will take two 20 mg omeprazole tablets and two 81 mg aspirin tablets each day before the first meal each day for 25-45 days. The study does involve biopsies of the colorectal tissue before and after taking the study medications. The biopsies are samples of tissue, about the size of a grain of rice, that will be taken from the colon or rectum before and after taking the study medications. This is done during a usual, clinical colonoscopy exam and during one more limited exam, called flexible sigmoidoscopy, that is done for the research study. The flexible sigmoidoscopy requires less preparation. Which procedure comes first depends on what fits best with each participant's clinical scenario. Biopsies of both normal mucosa and polyps (if possible) are collected.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 24
• Est. completion date: August 2024
• Est. primary completion date: August 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• Age 18-75
• Individuals who are due for a standard of care colonoscopy.
• Have a prior history of colorectal neoplasia including any ONE of the following:
• Multiple (>=5) colorectal adenomas on most recent colonoscopy
• Multiple (>=5) sessile serrated polyps on most recent colonoscopy
• Serrated polyps meeting criteria for serrated polyposis syndrome
• History of incompletely resected colorectal polyp(s) (adenoma or sessile serrated polyp) on most recent colonoscopy
• Willing to avoid taking non-steroidal anti-inflammatory drugs that are not provided by the study in the 30 days prior to Visit 1 and while on study.
• Willing to avoid taking proton pump inhibitors that are not provided by the study in the 30 days prior to Visit 1 and while on study.
• Women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) for the duration of study participation since endoscopy is not recommended during pregnancy.
• Demonstrate adequate organ and marrow function obtained within the last 60 days as

defined below:

• Absolute neutrophil count =1,000/microliter
• Platelets =100,000/microliter
• Total bilirubin = 1.5 fold of the institutional upper limit of normal Note:

Higher total bilirubin levels (= 3 mg/dL) can be allowed if due to known benign liver condition such as Gilbert's

• AST (SGOT)/ALT (SGPT) =3.0 fold of the institutional upper limit of normal
• Creatinine =1.5 fold of the institutional upper limit of normal
• Patients on chronic suppressive antiviral therapy for herpes simplex virus (HSV) are eligible.
• Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial.
• For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated.
• Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

• Age 76 or higher since there is an increased risk of GI bleeding and peptic ulcer disease in persons above 75 years of age.
• Pathogenic germline variants in adenomatous polyposis coli (APC) and DNA mismatch repair (MMR) genes associated with Lynch Syndrome, or biallelic pathogenic germline variants in the MutY homologue glycosylase (MUTYH) gene.
• Have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to proton pump inhibitors and/or aspirin.
• Participants may not be receiving any other investigational agents.
• Have a history of prior aspirin or NSAID gastritis with bleeding.
• Currently taking a proton pump inhibitor and unable/unwilling to discontinue use 30 days prior to Visit 1.
• Taking NSAIDs or aspirin >25% of the time (>8 days/month) and unable/unwilling to discontinue use 30 days prior to Visit 1 and until Visit 4.
• Currently taking medications associated with increased risk for bleeding (warfarin, Eliquis, Plavix, etc.).
• Currently taking medications that have interactions with omeprazole: atazanavir, erlotinib, levoketoconazole, nelfinavir, pazopanib, rilpivirine, sparsentan, certain azole antifungals (itraconazole, ketoconazole, and posaconazole).
• Have a history of hemophilia, Von Willebrand disease or any other known bleeding diathesis.
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• Individuals who the site physician investigator assesses as at high risk for bleeding due to heavy alcohol use or comorbid conditions.
• Pregnant women are excluded since endoscopy is not recommended while pregnant.
• Have invasive cancer or being treated for invasive cancer at the current time or within the past 36 months, with the exception of cancers curatively removed by surgery, other than melanoma, and stage I and II cervical squamous cell cancers.

Related Conditions & MeSH terms

• Colorectal Neoplasia
• Neoplasms

Intervention

Drug:
• Omeprazole
Two 20 mg/day omeprazole tablets taken before the first meal each day for 25-45 days.
• Aspirin
Two 81 mg/day aspirin tablets taken before the first meal each day for 25-45 days.

Locations

Country	Name	City	State
United States	The University of Michigan Rogel Cancer Center	Ann Arbor	Michigan
United States	Ohio State University Comprehensive Cancer Center	Columbus	Ohio

Sponsors (2)

Lead Sponsor	Collaborator
University of Michigan Rogel Cancer Center	National Cancer Institute (NCI)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Identification of biomarkers for omeprazole/aspirin combination treatment in the human colorectum	The ratio of Ki67 proliferation marker to cleaved caspase 3 apoptosis marker, and changes in gene expression by high throughput RNA sequencing (RNA-Seq).	up to 45 days from intervention initiation
Secondary	Evaluation of gene expression changes	To compare gene expression changes by RNA-Seq observed in the clinical trial with that observed in a well-characterized rodent colon cancer prevention model to evaluate potential for preventive efficacy.	up to 45 days from intervention initiation