Effects of a Western-type Diet on Colorectal Inflammation

Colorectal Inflammation Clinical Trial

Official title: Effects of a Western-type Diet on Colorectal Inflammation, Gut Permeability and Systemic Endotoxemia

Status Completed

Clinical Trial Summary

This study will look at the inflammatory (changes usually associated with infection/injury to the body) and bowel permeability (bowel's ability to allow contents to enter the body) effects of a Western-style diet (high fat and low in calcium) and a prudent-style diet (low fat and high in calcium) on the colon (large bowel). This study may provide information to prevent colorectal cancer in a high-risk population

Clinical Trial Description

Hypothesis: Compared to a prudent-style diet, does a western-style diet increase colorectal inflammation thereby increasing gut permeability and causing increased endotoxins and markers of systemic inflammation.

This is a single blind crossover study. Subjects will be randomized to begin on either a WD or a PD for 30 + 3 days. Once that dietary intervention is complete, subjects will have a four (4) week wash-out period and then will be placed on the other dietary intervention for 30 + 3 days. The following study measures are performed during both the dietary intervention study periods. All the baseline tests will be repeated at the end of each dietary intervention period. ;

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Colorectal Inflammation
• Inflammation

• NCT number: NCT00866450
• Study type: Interventional
• Source: Rockefeller University
• Status: Completed
• Phase: Phase 0
• Start date: February 2009
• Completion date: February 2010