Colorectal Cancer Stage IV Clinical Trial
Official title:
Matrilysin Expression in Different Stages of Colorectal Tumors
Matrix metalloproteinases (MMPs) have been shown to be involved in cancer biology.
Significant expression of MMP-7 (matrilysin) in colorectal cancer is mainly associated with
metastatic disease even though it is expressed in most tumor states. Our purpose is to
analyse MMP-7 in bowel and lymph nodes of different tumor stages and to evaluate its
expression as a potential biomarker of cancer disease in patients surgically treated for
benign and malignant colorectal tumors. Tumoral tissue, lymph nodes and serum samples from
recruited Patients plus serum samples from healthy volunteers are analysed for matrilysin
expression by histology, immunohistochemistry, ELISA and Western blotting.
If Matrilysin increases with increasing dysplasia and cancer disease stage in tumor tissue
as well as in the regional lymph nodes it might be used as a complement in investigating
suspected locally advanced cancer.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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