A Study of TRK-950 in Patients With Advanced Solid Tumors

Status Completed

Clinical Trial Summary

1. To determine the maximum tolerated dose (MTD) and the dose limiting toxicities (DLTs) of TRK-950 as single agent 2. To establish the dose of TRK-950 recommended for future phase 2 studies

Clinical Trial Description

This study is a first-in-human study of TRK-950 in patients with advanced solid tumors and is primarily designed to determine the dose-limiting toxicities (DLT) and maximum tolerated dose (MTD) of TRK-950 administered via intravenous (IV) infusion once weekly for 3 weeks every 28 days in Arm 1. Once enrollment in Arm 1 was completed, two dose schedules will be evaluated in Arm 2 to determine the dosing schedule. Up to six (6) patients will be enrolled respectively. In parallel, to determine anti-tumor activity up to twelve (12) patients will be enrolled in Arm 3. ;

Study Design

Related Conditions & MeSH terms

Cholangiocarcinoma
Colon Cancer
Locally Advanced or Metastatic Solid Carcinomas

Clinical Trial Details

NCT number	NCT02990481
Study type	Interventional
Source	Toray Industries, Inc
Contact
Status	Completed
Phase	Phase 1
Start date	March 6, 2017
Completion date	September 16, 2019

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