Cognitive Impairment Clinical Trial
Official title:
Predicting Cognition After DBS for Parkinson's Disease 2
The aim of the study is to improve estimation of cognitive outcome after STN-DBS in PD in order to avoid risk factors by optimizing peri- and intraoperative management personalize therapeutic strategies for optimal long-term benefit. The investigators will test possible predictors (clinical, neuropsychological, neuroimaging, electrophysiological and molecular) for the risk of cognitive dysfunction after deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson's disease (PD) at a single center (Charité - Universitätsmedizin Berlin, Germany). Data collection takes place prior to as well as 3, 12 and 60 months after the STN-DBS operation. Participation is proposed to all PD patients that are planned to undergo STN-DBS after careful examination of eligibility for this treatment according to standard operation procedures.
Status | Not yet recruiting |
Enrollment | 30 |
Est. completion date | December 1, 2030 |
Est. primary completion date | December 1, 2027 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: - Diagnosis of idiopathic Parkinson's Disease - Indication for STN-DBS Exclusion Criteria: - Internistic, surgical or psychiatric contrainidications with respect to the DBS operation or treatment for the STN-DBS group - Dementia - Relevant language barrier |
Country | Name | City | State |
---|---|---|---|
Germany | Charité - Universitätsmedizin Berlin | Berlin |
Lead Sponsor | Collaborator |
---|---|
Charite University, Berlin, Germany |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in cognitive performance after STN-DBS | Based on cognitive screening by Cambridge CANTAB Connect | Difference between pre, 12 and 60 months postoperative testing | |
Primary | Incidence of postoperative neurocognitive disorder | Based on cognitive screening by paper pencil test (MoCA) | Difference between pre, 12 and 60 months postoperative testing |
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