Cognitive Impairment Clinical Trial
Official title:
Prediction of Delayed Cognitive Impairment in Cardiac Arrest Survivors With Good Neurological Outcomes
Verified date | March 2023 |
Source | Chungnam National University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational [Patient Registry] |
The objective of this observational study is to provide basic data for predicting and analyzing the occurrence and causes of delayed cognitive impairment, an important factor in the quality of life, among discharged patients who have received targeted temperature management therapy and experienced favorable neurological outcomes after out-of-hospital cardiac arrest. The main questions it aims to answer are: - Can we identify abnormal areas in the brains of patients with delayed cognitive impairment using Brain MRI or positron emission tomography (PET) imaging? - Is it possible to predict delayed cognitive impairment using biomarkers?
Status | Enrolling by invitation |
Enrollment | 40 |
Est. completion date | September 30, 2027 |
Est. primary completion date | March 31, 2027 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Patients who visited the hospital emergency room due to cardiac arrest within 60 months after Institutional Review Board (IRB) approval - Patients with Glasgow Coma Scale (GCS) less than 8 points after spontaneous circulation recovery - Patients who are 18 years old or older - Patients who underwent targeted temperature management (TTM) - Patients who showed good neurological outcomes with CPC 1-2 points after evaluating the prognosis on days 10-14 after ROSC Exclusion Criteria: - Under 18 years of age - cardiac arrest cause is trauma - Patients who have not undergone targeted temperature management - Patients treated with extracorporeal membrane oxygenation (ECMO) - Patients who were not able to undergo SNSB testing - Patients who could not be followed up until 6 months after ROSC |
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | ??? | Daejeon | Seo-gu |
Lead Sponsor | Collaborator |
---|---|
Chungnam National University Hospital |
Korea, Republic of,
Bronnick K, Evald L, Duez CHV, Grejs AM, Jeppesen AN, Kirkegaard H, Nielsen JF, Soreide E. Biomarker prognostication of cognitive impairment may be feasible even in out-of hospital cardical arrest survivors with good neurological outcome. Resuscitation. 2 — View Citation
Cronberg T, Greer DM, Lilja G, Moulaert V, Swindell P, Rossetti AO. Brain injury after cardiac arrest: from prognostication of comatose patients to rehabilitation. Lancet Neurol. 2020 Jul;19(7):611-622. doi: 10.1016/S1474-4422(20)30117-4. — View Citation
Elliott VJ, Rodgers DL, Brett SJ. Systematic review of quality of life and other patient-centred outcomes after cardiac arrest survival. Resuscitation. 2011 Mar;82(3):247-56. doi: 10.1016/j.resuscitation.2010.10.030. Epub 2011 Jan 8. — View Citation
Moulaert VR, Verbunt JA, van Heugten CM, Wade DT. Cognitive impairments in survivors of out-of-hospital cardiac arrest: a systematic review. Resuscitation. 2009 Mar;80(3):297-305. doi: 10.1016/j.resuscitation.2008.10.034. Epub 2008 Dec 30. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in cognitive impairment | Through the Seoul Neuropsychological Screening Battery (SNSB), attention, language and related functions, visuospatial function, memory, frontal lobe and executive function, and other related functions can be assessed. The test is conducted by a specialist clinical psychologist for 1 hour and 30 minutes to 2 hours, and the results are analyzed by Professor Oh Eung-Seok, a neurologist. | at 10-14 days, 3 months, and 6 months after return of spontaneous circulation |
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