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Cardiac Arrest, Out-Of-Hospital clinical trials

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NCT ID: NCT06249893 Recruiting - Clinical trials for Cardiac Arrest, Out-Of-Hospital

Feasibility of Doppler Ultrasound for Pulse Detection in Out-of-Hospital Cardiac Arrest Patients

Start date: January 4, 2024
Phase:
Study type: Observational

The goal of this prospective observational study is to investigate the feasibility of using doppler point-of-care ultrasound on the femoral artery with a portable device to assess the presence of a pulse in patients suffering from cardiac arrest in the out-of-hospital environment. The main question is how often researchers are successful in acquiring the necessary ultrasound signal in the out-of-hospital environment.

NCT ID: NCT06165081 Recruiting - Clinical trials for Cardiac Arrest, Out-Of-Hospital

The Association Between Post-resuscitation Time Series Management in the Emergency Department and Short-term Outcomes for Out-of-hospital Cardiac Arrest Patients

Start date: January 1, 2024
Phase:
Study type: Observational

This study examines the impact of emergency department (ED) management on short-term outcomes of nontraumatic adult out-of-hospital cardiac arrest (OHCA) patients. Conducted by a research team at National Taiwan University Hospital and its affiliated hospitals, including branches in Hsinchu and Yunlin, the study spans from January 2016 to August 2023. It focuses on a sequential population of patients, analyzing data like age, gender, medical history, prehospital care details (e.g., witnessed collapse, bystander CPR), and specifics of ED management. OHCA, with an incidence rate of 50-100 per 100,000 people, presents high mortality and severe complications, leading to significant healthcare expenditures. After resuscitation in the ED, only about one-fifth of patients achieve return of spontaneous circulation (ROSC). The prognosis for these patients remains grim, with a mere 5% experiencing favorable neurological outcomes. Understanding the mechanisms of OHCA, identifying risk factors, effective interventions, and the timing of ED treatments like vasopressors and electrocardiography are crucial. Patients post-OHCA often undergo a postcardiac arrest syndrome (PCAS), marked by cellular hypoxia and a consequential inflammatory response. Stability of vital signs and rapid ED interventions, including identifying OHCA causes and coordinating with specialists, are vital for short-term recovery. This study aims to determine if ED management and time-related factors from ROSC to various interventions (e.g., ECG, CT scans) affect short-term survival rates, including survival to hospital admission and survival after 1, 3, and 7 days. By retrospectively analyzing patient data, including Utstein Style prehospital cardiac arrest registry variables and emergency department management details, the study seeks to shed light on the crucial phase of post-resuscitation care. The ultimate goal is to improve survival rates and neurological outcomes in OHCA patients, emphasizing the need for more comprehensive research in this area

NCT ID: NCT05908500 Recruiting - Clinical trials for Cardiac Arrest, Out-Of-Hospital

Overcoming Barriers to Performing CPR Using a Novel, Interactive CPR Game System

Start date: January 1, 2024
Phase: N/A
Study type: Interventional

The goal of this prospective trial is to compare CPR skill and attitudes in adolescent students. The main question[s] it aims to answer are: - Does a gamified CPR experience improve CPR skill retention compared to standard classroom CPR training? - Does a gamified CPR experience improve attitudes/knowledge relating to barriers for women and minorities receiving CPR? Participants will - Answer pre-training questionnaires - Participate in CPR training - Participate in CPR skills testing on the day of training, and at 4-6 months - Answer post-training questionnaires Researchers will compare standard CPR classroom training to the novel gamified CPR training experience, which includes an interactive film, a CPR Trainer spring, and a mobile device app.

NCT ID: NCT05830422 Enrolling by invitation - Clinical trials for Cognitive Impairment

Prediction of Delayed Cognitive Impairment in Cardiac Arrest Survivors With Good Neurological Outcomes

Start date: November 1, 2023
Phase:
Study type: Observational [Patient Registry]

The objective of this observational study is to provide basic data for predicting and analyzing the occurrence and causes of delayed cognitive impairment, an important factor in the quality of life, among discharged patients who have received targeted temperature management therapy and experienced favorable neurological outcomes after out-of-hospital cardiac arrest. The main questions it aims to answer are: - Can we identify abnormal areas in the brains of patients with delayed cognitive impairment using Brain MRI or positron emission tomography (PET) imaging? - Is it possible to predict delayed cognitive impairment using biomarkers?

NCT ID: NCT05588024 Recruiting - Clinical trials for Cardiac Arrest, Out-Of-Hospital

International Device Assisted Controlled Sequential Elevation CPR Registry

Start date: March 23, 2020
Phase:
Study type: Observational

The purpose of this prospective observational cardiopulmonary resuscitation (CPR) registry is to track the use and clinical outcomes from emergency medical systems across the US and Europe that have implemented a system of care approach applied rapidly to cardiac arrest that includes using the combination of an impedance threshold device (ITD), and either manual active compression-decompression (ACD) CPR device or automated compression device, with a Head Up CPR device.

NCT ID: NCT05482945 Recruiting - Clinical trials for Cardiac Arrest, Out-Of-Hospital

CardioPulmonary Resuscitation With Argon (CPAr) Trial

CPAr
Start date: May 30, 2022
Phase: N/A
Study type: Interventional

Preclinical studies suggest that argon (Ar) might diminish the neurological and myocardial damage after any hypoxic-ischemic insult. Indeed, Ar has been tested in different models of ischemic insult, at concentrations ranging from 20% up to 80%. Overall, Ar emerged as a protective agent on cells, tissues and organs, showing less cell death, reduced infarct size and faster functional recovery. More specifically, encouraging data has been reported in animal studies on cardiac arrest (CA) in which a better and faster neurological recovery was achieved when Ar was used in the post-resuscitation ventilation. More importantly, these benefits have been replicated in different studies, enrolling both small and large animals. Finally, ventilation with Ar in O2 has been demonstrated to be safe both in animals and humans. Based on this evidence, a clinical translation is advocated. Thus, the CardioPulmonary resuscitation with Argon - CPAr trial has been conceived. The aim of the CPAr trial is to evaluate feasibility and safety of Ar/O2 ventilation in patients resuscitated from CA. Activity endpoints will be also evaluated to assess effects of Ar.

NCT ID: NCT05376267 Recruiting - Clinical trials for Hypoxia-Ischemia, Brain

Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)

Start date: August 5, 2022
Phase: N/A
Study type: Interventional

This is a multicenter trial to establish the efficacy of cooling and the optimal duration of induced hypothermia for neuroprotection in pediatric comatose survivors of cardiac arrest. The study team hypothesizes that longer durations of cooling may improve either the proportion of children that attain a good neurobehavioral recovery or may result in better recovery among the proportion already categorized as having a good outcome.

NCT ID: NCT05325385 Not yet recruiting - Clinical trials for Ventricular Fibrillation

Ventricular Fibrillation Following Out-of-hospital Cardiac Arrest

Start date: September 2022
Phase:
Study type: Observational [Patient Registry]

The majority of survivors suffering an out-of-hospital cardiac arrest (OHCA) are those who initially present with a shockable rhythm, which is usually ventricular fibrillation (VF). When untreated, VF progresses to asystole over a short period of time so the percentage of those with a survivable rhythm also decreases with time. There is relatively little data exploring the initial rate of VF and the time course of its subsequent progression to a non-shockable rhythm. An understanding of this data will give a better picture of how potentially survivable rhythms (VF) change with time and guide the response times that are required to ensure arrival before VF deteriorates to asystole. The Investigators will use the UK OHCA outcomes database to examine the percentage of patients presenting with VF as the initial rhythm according to time since collapse in order to establish the rate at which VF deteriorates to asystole.

NCT ID: NCT05236920 Withdrawn - Clinical trials for Ventricular Tachycardia

Utility and Procedural Feasibility of REBOA Operationalized for Non-Trauma Application (UP-FRONT)

UP-FRONT
Start date: October 1, 2022
Phase: N/A
Study type: Interventional

Single center randomized-controlled trial in out-of-hospital cardiac arrest (OHCA) patients. This study will investigate the feasibility and utility of the Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) procedure using a REBOA catheter device in patients who have experienced an OHCA and have not regained return of spontaneous circulation (ROSC).

NCT ID: NCT05013333 Enrolling by invitation - Clinical trials for Cardiac Arrest, Out-Of-Hospital

AED 3 Post-Approval Study

Start date: March 30, 2021
Phase: N/A
Study type: Interventional

Demonstrate appropriate CPR sensor placement on pediatric and adult patients and demonstrate delivery of appropriate energy level of shocks to pediatric and adult patients.