Effects of Huperzine A on Presbycusis(Δ,kHz, dB,MMSE, AD)

Status Enrolling by invitation

Clinical Trial Summary

To investigate the effects of huperzine A on tinnitus suppression, hearing and cognitive function protection in patients with presbycusis-related subjective tinnitus and cognitive impairment.

Clinical Trial Description

This study is a randomized, controlled trial. 60 eligible participants in total will be recruited. Participants in each group will be evenly and randomly assigned to the huperzine A subgroup and control subgroup using simple randomization method. Participants in the treatment subgroup will receive huperzine A (a dose of 0.2 mg/time, 2 times/day) with basic treatment and health education(BTHE), and those in the control subgroup will receive BTHE only. The primary outcome (auditory function) and secondary outcomes (tinnitus, cognitive symptom and quality of life) will be evaluated at baseline, 3-, 6-, 12-month follow-up. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03101722
Study type	Interventional
Source	Fudan University
Contact
Status	Enrolling by invitation
Phase	N/A
Start date	May 15, 2017
Completion date	December 1, 2023

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02122198` - Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women	N/A
Recruiting	`NCT04356924` - Psychological Treatment to Support the Consequences of Cognitive Impairment	N/A
Suspended	`NCT05542238` - The Effect of Acute Exercise on Cardiac Autonomic, Cerebrovascular, and Cognitive Function in Spinal Cord Injury	N/A
Terminated	`NCT04493957` - Evaluation of an Educational Program in the Prevention of the Driving Risks in Patients With Neurocognitive Disorders : ACCOMPAGNE	N/A
Recruiting	`NCT04792983` - Cognition and the Immunology of Postoperative Outcomes
Completed	`NCT06029920` - Influence of Overground Walking on Biomarkers, Cognitive Function, and Quality of Life in Elderly With Mild Cognitive Impairment	N/A
Not yet recruiting	`NCT05068323` - Impact of Interictal Epileptiform Activity on Some Cognitive Domains in Newly Diagnosed Epileptic Patients	N/A
Completed	`NCT04426838` - Cognitive Behavioral Therapy for Insomnia for the Dementia Caregiving Dyad	N/A
Completed	`NCT04713384` - Remote Bimanual Virtual Rehabilitation Post CVD	N/A
Recruiting	`NCT06284213` - Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium
Recruiting	`NCT06053775` - Non-Invasive Brain Stimulation and Cognitive Training for Depressive Symptomatology Related to Breast Cancer (ONCODEP)	N/A
Completed	`NCT03698695` - A Pharmacodynamics, Safety, and Pharmacokinetics Study of THN201 Versus Donepezil in Healthy Male Volunteers	Phase 1
Not yet recruiting	`NCT05552729` - Effects of Different Doses of Vitamin D on Cancer-related Cognitive Impairment in Patients With Gastrointestinal Tumors	Phase 1/Phase 2
Recruiting	`NCT03268109` - COGnitive ImpairmenT in Older HIV-infected Patients ≥ 65 Years Old
Completed	`NCT03301402` - Air Purifier to Improve Endothelial Function and Carotid Intima Thickness	N/A
Completed	`NCT03187353` - IMProving Executive Function Study	Phase 4
Completed	`NCT05395559` - Prevalence and Recognition of Cognitive Impairment in Hospitalized Patients: a Flash Mob Study
Recruiting	`NCT04907565` - Impact of Obesity on Post-operative Cognitive Dysfunction: Role of Adipose Tissue
Recruiting	`NCT05030285` - Telehealth Psychotherapy for Anxiety in Persons With Cognitive Impairment	N/A
Recruiting	`NCT04897334` - Transcranial Direct Current Stimulation and Rehabilitation to Ameliorate Impairments in Neurocognition After Stroke	N/A