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Clinical Trial Summary

This is a randomized controlled human exposure crossover study. Investigators aims to assess the acute effects of low temperature exposure and the underlying mechanisms.


Clinical Trial Description

The investigators will conduct a randomized controlled human exposure crossover study among about 50 healthy young adults in Shanghai, China. Each subject will be exposed twice: once to the low temperature (16#) and once to the moderate temperature (22#) in a chamber for about 2-2.5 hours. During the exposure session, each subject will be requested to rest. Health examinations will be conducted immediately prior to exposure (within 1 hour before the exposure session), during the period of exposure, and after exposure (within 2 hours after the exposure session). Health examinations include spirometry, Holter monitoring, blood pressure tests, cognitive function tests, symptom questionnaires, and magnetic resonance imaging. Investigators plan to collect blood, urine, exhaled breath condensate, and oropharyngeal swabs samples. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06076629
Study type Interventional
Source Fudan University
Contact Haidong Kan, PhD
Phone +86-021-54237908
Email kanh@fudan.edu.cn
Status Not yet recruiting
Phase N/A
Start date October 10, 2023
Completion date December 31, 2024

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