Effect of Acetaminophen Preemptive Analgesia on Postoperative Cognitive Function

Cognitive Function Clinical Trial

Official title:

Effects of Acetaminophen Preemptive Analgesia on Anesthesia Recovery Time and Postoperative Cognitive Function in Patients Undergoing Gastrointestinal Tumor Surgery

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06004687
• Other study ID #: zhhszjjh
• Status: Recruiting
• Phase: Phase 1/Phase 2
• Start date: July 26, 2023
• Est. completion date: December 30, 2024

Study information

• Verified date: July 2023
• Source: Affiliated Hospital of Nantong University
• Contact: Hongsheng Chen
• Phone: +86 513 81160313
• Email: chenhongsheng8[@]163.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Patients undergoing gastrointestinal tumor surgery are prone to delayed recovery and postoperative cognitive dysfunction due to greater trauma and longer operation time. Pre-analgesia can reverse the effects of nociceptive stimulation on recovery from general anesthesia and postoperative cognitive function. Intravenous injection of non-steroidal drugs can effectively reduce postoperative pain and the use of opioids. Therefore, This study selected acetaminophen mannitol injection for preemptive analgesia to observe the effects on anesthesia recovery time and postoperative cognitive function of patients undergoing gastrointestinal tumor surgery, providing new ideas for reducing cognitive dysfunction in patients undergoing gastrointestinal tumor surgery

Description:

By administering acetaminophen to patients with gastrointestinal tumors before surgery, recording the time to recovery from anesthesia, and assessing cognitive function status by CAM on the first, third, and seventh day after surgery

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: December 30, 2024
• Est. primary completion date: May 30, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 16 Years to 88 Years

Eligibility

Inclusion Criteria:

• Patients undergoing gastrointestinal tumor surgery

• American Society of Anesthesiologists(ASA)=?

Exclusion Criteria:

• History of severe adverse reactions to oral acetaminophen

• Dysfunction of heart, liver, kidney and other important organs

• History of chronic pain

• Oral non-steroidal or opioid drugs

• Patients who do not accept clinical trials

Related Conditions & MeSH terms

• Cognitive Function

Intervention

Drug:
• acetaminophen mannitol
Intravenous acetaminophen was administered 30 minutes before anesthesia
• Normal saline
Intravenous acetaminophen was administered 30 minutes before anesthesia

Locations

Country	Name	City	State
China	Affiliated Hospital of nantong University	Nantong	Jiangsu

Sponsors (1)

Lead Sponsor	Collaborator
Affiliated Hospital of Nantong University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Neurotransmitters in the blood	Neurotransmitters include epinephrine, norepinephrine, and so on	1/3/7 days after the surgery
Primary	Postoperative delirium	The confusion assessment method (CAM) was used to assess postoperative cognitive dysfunction	1/3/7 days after the surgery
Secondary	Recovery time	The postoperative recovery time was recorded	immediately after the surgery