Clinical Trial Details
— Status: Recruiting
Administrative data
NCT number |
NCT03542734 |
Other study ID # |
CIRCLE-CHINA |
Secondary ID |
|
Status |
Recruiting |
Phase |
|
First received |
|
Last updated |
|
Start date |
January 1, 2010 |
Est. completion date |
June 30, 2031 |
Study information
Verified date |
January 2023 |
Source |
Second Affiliated Hospital, School of Medicine, Zhejiang University |
Contact |
Min Lou, Ph.D |
Phone |
13958007213 |
Email |
loumingxc[@]vip.sina.com |
Is FDA regulated |
No |
Health authority |
|
Study type |
Observational [Patient Registry]
|
Clinical Trial Summary
The CIRCLE study is a single-center prospective observational study that enrolled individuals
with cerebral small vessel disease (SVD), while free of known dementia or stroke (both
cerebral infarction and hemorrhage). The patients will receive neuropsychological testing,
retinal digital images and multimodal magnetic resonance imaging (MRI). Blood samples will
also be collected. Recent small subcortical infarcts, lacunes, white matter hyperintensities,
perivascular spaces, microbleeds, and brain atrophy will be evaluated on both baseline and
follow-up brain MRIs. The investigators will explore the predictors of preogression of SVD
and cognitive deficits.
Description:
Cerebral small vessel disease (SVD) is commonly detected in elderly individuals, and patients
with stroke or neurodegenerative disease. Features seen on neuroimaging include recent small
subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces,
microbleeds, and brain atrophy. Previous studies indicated that SVD was associated with an
increased risk of stroke and stroke recurrence, cognitive deficits, physical disabilities,
and mortality. However the pathogenesis of SVD is largely unknown. Little is known about how
SVD lesions contribute to neurological or cognitive symptoms, and the association with risk
factors. Recent data sugessted concomitant SVDs and retinopathy is associated with a profile
of vascular cognitive impairment. In this study, the investigators try to explore the new
pathological mechanism of SVD, the new predictors for SVD progression, and the association
with cognitive Impairment, based on digital retinal images and brain multimodal imaging
technique.