Cognitive Decline Clinical Trial
— HOPE-DIETOfficial title:
Healthy Older People Everyday (HOPE) - Role of Healthy Diet on Muscle and Bone Health
Verified date | December 2018 |
Source | National University Hospital, Singapore |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Certain clinical syndromes eg frailty, sarcopenia, dementia, depression, cognitive
impairment, vision impairment and falls in older adults carry an increased risk for poor
health outcomes and if identified early, can be prevented, delayed or reversible. There is
evidence to suggest that exercise and dietary intervention can help delay or prevent
sarcopenia, frailty and dementia.
The current hypothesis is older adults do not consume enough protein in their diet. Local
delicacies enhanced with protein content, in addition to physical activity will improve
muscle strength, function, perceived health status and possibly may even reverse frailty and
sarcopenia. Additionally, it is hypothesized that combination of multi component group
exercise activities and high protein nutrition will be effective in improving participants'
social, mental and physical status.
Status | Not yet recruiting |
Enrollment | 1000 |
Est. completion date | December 2020 |
Est. primary completion date | December 2020 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 65 Years and older |
Eligibility |
Inclusion Criteria: - At least pre-frail (Frail scale score of at least 1) but ambulant - Grip strength not more than 25kg for males and 18kg for females Exclusion Criteria: - With kidney conditions |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
National University Hospital, Singapore | Health Promotion Board (HPB), Saw Swee Hock Shool of Public Health, National University of Singapore |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Changes in frailty status | Changes in frailty status by 5-item FRAIL scale Scale range from 0 to 5, the higher the value, the more frail. | 2 years | |
Primary | Changes in lower extremity physical performance | Changes in short physical performance battery (SPPB) summary score 3 subscales (range from 0 to 4 for balance, gait speed and chair stand) summed to give total score range from 0 to 12. The higher the value, the better the performance of lower extremity. |
2 years | |
Secondary | Changes in upper extremity muscle strength | Changes in handgrip strength test performance (kg) | 2 years | |
Secondary | Changes in skeletal muscle mass | Changes in skeletal muscle mass by bioelectrical impedance analysis | 2 years | |
Secondary | Changes in sarcopenic status | Changes in sarcopenic status by SARC-F scale Scale range from 0 to 10, the higher the value, the greater the likelihood of sarcopenic | 2 years | |
Secondary | Changes in mood | Changes in Geriatric Depression Scale (GDS) Scale range from 0 to 15, the higher the score, the greater the likelihood of depression. | 2 years | |
Secondary | Changes in mood | Changes in UCLA Loneliness Scale Scale range from 0 to 9, the higher the value, the greater the loneliness Scale from 0 to | 2 years | |
Secondary | Changes in cognitive function | Changes in Mini Mental State Examination (MMSE) score 5 subscales: Orientation (0 to 10), Registration (0 to 3), Attention and Calculation (0 to 5), Recall (0 to 3), Language and Praxis (0 to 9) Total scale range from 0 to 30, the higher the value, the less cognitive impairment. | 2 years | |
Secondary | Changes in cognitive function | Changes in Montreal Cognitive Assessment (MoCA) | 2 years | |
Secondary | Changes in nutritional status | Changes in Mini Nutritional Assessment (MNA) score 2 Subscales: Screening (0 to 14) and Assessment (0 to 16) Total scale range from 0 to 30, the higher the value, the more well nourished. | 2 years | |
Secondary | Changes in functional status (instrumental activities of daily living) | Changes in Instrumental Activities of Daily Living (IADL) score Scale range from 0 to 8, the higher the value, the greater the ability. | 2 years | |
Secondary | Changes in functional status (activities of daily living) | Changes in Activities of Daily Living (ADL) score Scale range from 0 to 6, the higher the value, the greater the ability. | 2 years | |
Secondary | Changes in fall risk | Changes in fall efficacy questionnaire | 2 years | |
Secondary | Incidence of self-reported falls | Number of falls assessed by questionnaires | 2 years | |
Secondary | Changes in quality of life | Changes in EuroQoL-5D (EQ5D) score 5 subscales (1 to 5): Mobility, self-care, usual activities, pain/discomfort, anxiety/depressed Each subscale assessed individually. | 2 years | |
Secondary | Changes in social engagement | Changes in Lubben Social Network Scale. Scale range from 0 to 30, the higher the value, the greater the social engagement | 2 years | |
Secondary | Changes in systemic inflammation | Changes in Tumour necrosis factor alpha (TNF-a) | 2 years | |
Secondary | Changes in systemic inflammation | Changes in Interleukin-10 | 2 years | |
Secondary | Changes in systemic inflammation | Changes in Interleukin-6 | 2 years | |
Secondary | Changes in phase angle by bioelectrical impedance analysis | Changes in phase angle by bioelectrical impedance analysis | 2 years | |
Secondary | Changes in protein mass | Changes in protein mass by bioelectrical impedance analysis | 2 years | |
Secondary | Changes in level of bone biomarkers | Changes in level of serum sclerotin | 2 years | |
Secondary | Changes in level of bone biomarkers | Changes in level of serum osteocalcin | 2 years | |
Secondary | Changes in level of bone biomarkers | Changes in level of free Vitamin D | 2 years | |
Secondary | Acceptance of protein enriched food by local seniors | Assessed by taste test questionnaire | 2 years | |
Secondary | Cost-effectiveness analysis | Cost effectiveness will be evaluated from the societal perspective. Cost of the program as well as healthcare utilization related to frailty and sarcopenia will be collected. An incremental cost effectiveness ratio will be computed by identifying the additional costs associated with the Intervention Group per additional unit of health outcome (QALYs). | 2 years |
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