Effects of Blueberry Juice Consumption on Cognitive Function in Healthy Older People

Cognitive Aging Clinical Trial

Official title:

Effects of Blueberry Juice Consumption on Brain Activation and Perfusion in Healthy Older People

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02985580
• Other study ID #: 1314/134617
• Status: Completed
• Phase: N/A
• First received: September 13, 2016
• Last updated: December 2, 2016
• Start date: October 2013
• Est. completion date: September 2014

Study information

• Verified date: September 2016
• Source: University of Exeter
• Contact: n/a
• Is FDA regulated: No
• Health authority: UK: University of Exeter
• Study type: Interventional

Clinical Trial Summary

Blueberries are rich in flavonoids that possess antioxidant and anti-inflammatory properties, which in rodent models are neuro-protective. The risk of developing dementia is reduced in people habitually consuming high flavonoid intakes, but data from human intervention studies is sparse. We therefore investigated whether 12 weeks of blueberry concentrate supplementation improved cognitive function in healthy elderly via increased brain activation and perfusion.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 26
• Est. completion date: September 2014
• Est. primary completion date: September 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 60 Years to 80 Years

Eligibility

Inclusion Criteria:

• aged 60-80y

• Addenbrooke's Cognitive Examination III questionnaire > 88

• Consuming 5 or less portions of fruit per day

Exclusion Criteria:

Addenbrooke's Cognitive Examination III questionnaire < 88 Contraindications for MRI Consuming more than 5 portions of fruit per day

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Cognitive Aging

Intervention

Dietary Supplement:
• Blueberry

• Placebo

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Exeter

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Brain perfusion	MRI - arterial spin labelling	Change from baseline to 12 weeks dietary supplementation	No
Secondary	Brain activation	fMRI whilst performing modified Stroop task	Change from baseline to 12 weeks dietary supplementation	No
Secondary	Cognitive function tests	Cogstate battery of tests	Change from baseline to 12 weeks dietary supplementation	No
Secondary	Blood biomarkers of inflammation	CRP, IL6,	Change from baseline to 12 weeks dietary supplementation	No
Secondary	Blood biomarkers of oxidative stress	protein carbonyls, glutathione	Change from baseline to 12 weeks dietary supplementation	No
Secondary	Blood biomarkers of neurogenesis	BDNF	Change from baseline to 12 weeks dietary supplementation	No