Cognitive Aging Clinical Trial
— MACSOfficial title:
A 14 Week Study of Mindfulness Effects on Attentional Control in Older Adults (The MACS Study: Mindfulness and Attentional Control in Seniors)
Verified date | February 2019 |
Source | University of Florida |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Attentional control, or individuals' ability to choose which stimuli in the environment they
attend to and which they ignore, declines with older age. Studies from the past two decades
suggest that mindfulness meditative practice, such as a standardized mindfulness based stress
reduction programs, may increase the efficiency of attention networks.To date, the majority
of studies that have related mindfulness meditation practice to attentional control have been
based on retrospective self-reported mindfulness or cross-sectional measurement in
experienced meditators. More recent experimental studies using pre-post training designs have
shown that meditation-naïve individuals can experience attentional improvement with
mindfulness intervention. This study seeks to elucidate the time course and process by which
such attentional improvements might be achieved.
This research study investigates change in attentional control as participants progress
through an 8-week mindfulness-inspired training (MIT) intervention, and has two specific
aims: 1) to determine the time course of change in attentional components such as cognitive
control and sustained attention as a consequence of MIT; attention will be measured weekly
for 3 weeks before, 3 weeks after, and during 8 weeks of MIT. 2) To investigate the extent to
which change in attentional performance is coupled/correlated with markers of emotion
regulation, perceived mindfulness, and perceived mind wandering.
Status | Completed |
Enrollment | 42 |
Est. completion date | February 28, 2018 |
Est. primary completion date | February 28, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 65 Years and older |
Eligibility |
Inclusion Criteria: - Able to provide informed consent and perform cognitive and behavioral (mindfulness) interventions; - Time and willingness to commit to the completion of this study; - Ability to read at an 8th grade level based on scores on the Wechsler Test of Adult Reading (WTAR) and reading text at 14 point font Exclusion Criteria: - Lack of time and willingness to commit to the completion of this 14-week study - Less than an 8th grade education - Having been told by a healthcare provider that they (1) have had a stroke or mini-stroke in the past 12 months, (2) have ever had a traumatic brain injury, (3) have had schizophrenia or psychosis, (4) have problem with alcohol or substance abuse - extreme difficulty reading ordinary print in a newspaper, or have stopped reading due to poor eyesight. - extreme difficulty hearing, or being completely unable to hear, ordinary speech in low-noise conditions, even with hearing aid. - Currently participating in cognitive training or brain training - Having participated in any cognitive or brain training study within the last 6 months - Currently participating in yoga or meditation based practices |
Country | Name | City | State |
---|---|---|---|
United States | The Vital Laboratory at the The Village | Gainesville | Florida |
Lead Sponsor | Collaborator |
---|---|
University of Florida | National Institute on Aging (NIA) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Self-ratings of Perceived Mind Wandering Over 8 Weekly Measurements | Participants in both arms are asked, at the end of each of their eight intervention sessions, to focus on breathing. They are interrupted five times during this breathing exercise and asked what proportion of their attention (0-100) was wandering off the breathing task. Score is the average proportion of self-rated mind-wandering over five probes. Scores have been normalized via Blom transformation and computed to T-score metric (mean=50, standard deviation = 10, minimum = 0, maximum = 100, higher = worse) | Self-ratings of weeks 4, 5, 6, 7, 8, 9, 10, 11 | |
Other | Self-ratings in Anxiety (GAD-7) Questionnaire Over 14 Weekly Measurements | Participants will answer computer 7 administered questions about anxiety in the past week. Score is a Likert-type scale response from the following scale: 0=not at all, 1=several days, 2=more than half the days, 3=nearly every day. Scores have been normalized via Blom transformation and computed to T-score metric (mean=50, standard deviation = 10, minimum = 0, maximum = 100, higher = worse) | Self-ratings in weeks 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 | |
Other | Self-ratings on Cognitive and Affective Mindfulness Scale (CAMSr) Over 14 Weekly Measurements | Cognitive and Affective Mindfulness Scale (CAMSr) will be computer administered. It is a psychological measurement to explore mindfulness. Each week ten items are rated on a 4-point Likert-type scale (1=rarely/never, 2=sometimes, 3=often, 4=almost always). Higher scores indicate greater cognitive and emotional focus. Scores are the average of the ten items, normalized and converted to T-score (mean=50, standard deviation = 10, minimum = 0, maximum = 100, higher = better) metric. | Self-ratings weeks 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 | |
Primary | Performance in Attention Network Task Conflict Monitoring Over 14 Weekly Measurements | The Attention Network Task is a computerized test that measures three different components of attention (alerting, orienting, and conflict monitoring). Score is the computed as the difference between reaction time on correct trials in cued and uncued conditions. Scores have been normalized via Blom transformation and computed to T-score metric (mean=50, standard deviation = 10, minimum = 0, maximum = 100, higher = worse) | Performance in weeks 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 | |
Secondary | Performance in Useful Field of View Over 14 Weekly Measurements | The useful field of view task is a computer-administered selective visual attention test that determines the minimum presentation time needed (between 16-500 msec) to correctly make two visual judgments: (a) is a centrally presented line drawing of a car or truck? and (b) where on the screen is a peripheral car located? Score is the fastest presentation time at which participants achieve at least 75% accuracy. Scores have been normalized via Blom transformation and computed to T-score metric (mean=50, standard deviation = 10, minimum = 0, maximum = 100, higher = worse) | Performance in weeks 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 | |
Secondary | Performance in Stroop Interference Over 14 Weekly Measurements | This task set is computerized presents participants with a word (red or green or blue) that may be presented in (a) congruent (same) color as the word itself (e.g., red word is printed in red), or (b) incongruent (word red printed in green or blue). Participants are cued to either select the word or the color, this varies from trial to trial. Score is the reaction time difference between correct responses to congruent and incongruent stimuli. Scores have been normalized via Blom transformation and computed to T-score metric (mean=50, standard deviation = 10, minimum = 0, maximum = 100, higher = worse) | Performance in weeks 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 |
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