Change in Brain Metabolism and Cognitive Function by Aripiprazole

Cognition Clinical Trial

Official title:

The Relationship Between D2 Occupancy and Change in Frontal Metabolism and Working Memory Induced by Aripiprazole

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01562808
• Other study ID #: A070001
• Status: Completed
• Phase: N/A
• First received: March 22, 2012
• Last updated: March 23, 2012
• Start date: January 2009
• Est. completion date: January 2012

Study information

• Verified date: March 2012
• Source: Seoul National University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Korea: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

Dopamine receptor occupancy and brain metabolism were measured using positron emission tomography after the administration of aripiprazole. Working memory performance was also measured using N-back task.

The investigators explored the relationship between changes in brain metabolism and working memory performance.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 15
• Est. completion date: January 2012
• Est. primary completion date: May 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 19 Years to 30 Years

Eligibility

Inclusion Criteria:

• healthy volunteers

• right-handed

Exclusion Criteria:

• any significant abnormality on routine lab

• any psychiatric disease

Study Design

Intervention Model: Single Group Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Antipsychotics
• Brain Metabolism
• Cognition
• Dopamine Receptor Occupancy

Intervention

Drug:
• Aripiprazole
single oral administration of aripiprazole

Locations

Country	Name	City	State
Korea, Republic of	Seoul National University Hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Seoul National University Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Reaction time of correct response in N-back task		48 hrs after the administration of aripiprazole	No