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Suvorexant and Cocaine

Cocaine Use Disorder Clinical Trial

Official title:
Influence of Orexin Antagonism on Motivation for Cocaine

Clinical Trial Summary

The research proposed here will translate findings from preclinical research and provide the initial clinical evidence that orexin antagonism reduces motivation for cocaine, as well as other cocaine-associated maladaptive behaviors in active cocaine users. This study will also provide basic science information about the orexinergic mechanisms underlying the pharmacodynamic effects of cocaine in humans. As such the outcomes will contribute to our understanding of the clinical neurobiology of cocaine use disorder. Overall, the proposed work seeks to expand the scope of current clinical neuroscience research on cocaine addiction by focusing on orexin, which has strong preclinical evidence supporting its critical role in addiction but remains unstudied in humans.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03937986
Study type Interventional
Source University of Kentucky
Contact
Status Completed
Phase Early Phase 1
Start date July 11, 2019
Completion date April 30, 2022
View Details
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