Cocaine-Related Disorders Clinical Trial
Official title:
Behavioral Strategies to Maximize the Efficacy of Pharmacotherapy for Cocaine Dependence: Relapse Prevention With Contingency Management Procedures
Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found. The purpose of this study is to examine the effectiveness of levodopa and carbidopa in treating cocaine dependent individuals. In addition, this study will examine the effects of incentive rewards for treatment compliance.
Cocaine is a strong central nervous system stimulant that is widely abused throughout the
United States. Due to its widespread use, it is important to develop an effective treatment
for cocaine dependence. Levodopa is a medication that is used alone or in combination with
carbidopa to treat Parkinson's disease. The purpose of this study is to determine the
possible interactions between behavioral interventions and carbidopa/levodopa in order to
treat cocaine dependent individuals.
This study will last 12 weeks and will involve two phases. The first phase will include
three therapy conditions: 1) clinical management only, 2) clinical management and relapse
prevention therapy, and 3) clinical management, relapse prevention therapy, and contingency
management. All of the conditions in the first phase will be evaluated incrementally under
active and placebo conditions while participants receive carbidopa/levodopa.
The second phase of the study will examine the contingency management procedure
applications. Each of the three contingency management procedure applications targets
specific behaviors that, when reinforced, may interact with carbidopa/levodopa to produce
clinical benefits. Participants will receive relapse prevention therapy combined with a
contingency management procedure that targets clinic attendance, medication compliance, and
cocaine abstinence. Study visits will occur weekly throughout the study. In addition,
participants will complete a one-year follow-up visit.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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