Coagulation Disorder Clinical Trial
Official title:
The ENDOCARDITIS AUMC Data Collection : a Matched Cohort Study on Perioperative Coagulation in Conservatively and Surgically Treated Patients With Valvular Dysfunction, With and Without Infective Endocarditis
The investigators will compare patients with and without infective ndocarditis undergoing valve surgery and evaluate factors that may help optimise perioperative care of these high-risk patients.
The aim of this study is to examine the differences between patients with and without endocarditis who undergo cardiothoracic (valve) surgery. In addition, the investigators will look at the differences between endocarditis patients who undergo surgery, and those who are treated conservatively. The investigators will look at incidence and degree of perioperative coagulation abnormalities, as well as transfusion and coagulation factor requirements, heparin resistance, bleeding scores, predictive endocarditis mortality scores, vasopressor-inotrope scores, and relate these where possible to the pathogen causing IE. The investigators will also look at perioperative complications, in particular, thromboembolic events and mortality at 30 and 90 days, and at 1 year. These outcomes may help optimise perioperative care for high-risk endocarditis patients, and in particular those undergoing valve surgery. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03826043 -
THrombo-Embolic Event in Onco-hematology
|
N/A | |
Recruiting |
NCT04274777 -
The Relationship Between Lipid Peroxidation Products From Traumatic Brain Injury and Secondary Coagulation Disorders
|
||
Recruiting |
NCT03136510 -
Evolution of Coagulation Activity in Non Valvular Atrial Fibrillation Patients Under Apixaban
|
N/A | |
Completed |
NCT01588132 -
Anfibatide Phase 1 Clinical Trial in Healthy Volunteers
|
Phase 1 | |
Recruiting |
NCT04488341 -
Effect of Aerobic Exercises on Sex Hormones and Coagulation Factors in Postmenopausal Elderly Women
|
N/A | |
Recruiting |
NCT04524637 -
The Utility of Thromboelastography in Traumatic Brain Injury
|
||
Completed |
NCT03634215 -
Estimation of Coagulation Factor XIII Activity Based on the Initial Plasma Fibrinogen Level in Trauma
|
||
Completed |
NCT05152420 -
Study of Intravenous VMX-C001 in Healthy Subjects and in Combination With Selected Direct Oral Anticoagulants in Healthy Older Subjects
|
Phase 1 | |
Recruiting |
NCT05645081 -
Extracellular Vesicles and Dysregulated Coagulation in the Prediction of Stroke
|
||
Completed |
NCT04322721 -
Coagulopathy on the First Postoperative Day Predicts the Long-term Survival of Traumatic Brain Injury Patients
|
||
Completed |
NCT03267823 -
INR Comparison Testing in Cardiac Surgery
|
||
Completed |
NCT04490759 -
QStat Pilot Reference Range Study
|
||
Completed |
NCT04107818 -
Comparison of Viscoelastic Measurement by ROTEM® Delta and ClotPro® in Trauma Patients.
|
||
Recruiting |
NCT05484830 -
Coagulation in Acute Aortic Dissection
|
N/A | |
Recruiting |
NCT04111120 -
Heparin Like Effect in Acute Variceal Bleeding
|
||
Completed |
NCT05162339 -
Inflammatory Bowel Disease and Thromboembolic Events
|
||
Completed |
NCT03555630 -
Thromboelastogram in Postdelivery Preeclamptic Patients
|
||
Completed |
NCT01589172 -
Evaluating the Use of Thromboelastography to Diagnose Coagulopathy After Traumatic Brain Injury
|
||
Recruiting |
NCT04278404 -
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
|
||
Completed |
NCT03956836 -
Perioperative Coagulopathy in Patients Undergoing Cytoreductive Surgery and HIPEC Intraperitoneal Chemotherapy (HIPEC)
|