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Clinical and Immunological Features of the CMV Infection Atypical Course in Immunocompetent Individuals

CMV Clinical Trial

Official title:
To Identify the Clinical and Immunological Features of the CMV Infection Atypical Course in Immunocompetent Individuals and to Develop Methods for the Diagnosis and Treatment of Patients in This Category

Clinical Trial Summary

Current study evaluates possible correlations between the content of various cell populations, the genetic material of the virus and antibodies to it in the blood of patients and the risk of thrombosis development in patients with acute CMV infection. А new method for the early detection of immunological and clinical signs of thromboembolic complications of CMV infection in immunocompetent individuals and the treatment of patients in this category will be developed.

Clinical Trial Description

- evaluate the immune status main indicators that characterize the activation of immune system, immunosuppression and anergy (myeloid suppressor cells, T-regulatory cells, T-cells according to the stages of differentiation (naive - effector - memory), activated T-cells); - identify and characterize immunological disorders in patients with CMV infection complicated by thromboembolism of various localization; - determine the presence and quantitative content in plasma / serum and neutrophils of the CMV genetic material by real-time PCR; - study humoral immunity to CMV (IgM / IgG antibodies to CMV in serum); - determine the content of CMV specific T-cells in peripheral blood; - develop a method for the early detection of immunological and clinical signs of thromboembolic complications of CMV infection in immunocompetent persons and treatment of patients in this category. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04392297
Study type Observational
Source The Republican Research and Practical Center for Epidemiology and Microbiology
Contact
Status Enrolling by invitation
Phase
Start date July 1, 2019
Completion date November 30, 2024
View Details
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