Clostridium Difficile Clinical Trial
Official title:
Prevention of Clostridium Difficile Infections Using Lactobacillus Plantarum 299v Strain in Nephrology and Transplantation Department
The aim of this study was to analyze whether the use of the LP299v strain reduces the risk of
Clostridium difficile infection (CDI) among patients receiving antibiotics and hospitalized
in the nephrology and transplantation ward.
Patients from risk group (receiving immunosuppressive drugs and treated with antibiotics)
were enrolled into study.
Participants will be divided into two groups. First group will receive one capsule of
Lactobacillus plantarum 299v (LP299v) orally per a day. Second group will receive placebo.
Clostridium difficile is currently the most frequently identified pathogen causing
antibiotic-associated diarrhoea and the main cause of nosocomial diarrhoea. In regard to
observed worldwide increase rate of infection and mortality from CDI the prevention of
Clostridium difficile infections seems to be crucial, especially in patients at CDI high
risk. So far, it has not been unambiguously proven that probiotics are effective in the
prevention of Clostridium difficile infection among patients undergoing antibiotic therapy.
The Lactobacillus plantarum 299v (LP299v) is a Gram-positive lactic acid bacteria that
naturally occurs on the surface of human intestinal mucosa. Specific properties to the gut
mucosa colonization are due to mannose-dependent adhesion of LP299v to the epithelium of
human intestines.This ability of LP299v leads to reduction of bacterial translocation from
the intestinal lumen into the blood vessels, can prevent adhesion of many pathogens to
intestinal epithelium and modulate the inflammatory response of the epithelium. The strain
299v of Lactobacillus plantarum has been found to decrease the severity of gastrointestinal
adverse effects during antibiotic therapy. Limited data are available regarding the efficacy
of LP299v for preventing Clostridium difficile infections.
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