Clostridium Difficile Infection Clinical Trial
Official title:
Pathogenic Mechanisms in Clostridium Difficile Infection and Colitis
The purpose of this study is to learn more about infection by Clostridium difficile (also
known as C. difficile). C. difficile is a common bacterium (a germ that may cause disease)
that can live in the human gut. Some people have it without having any symptoms. In other
people it can cause illness ranging from mild diarrhea to severe colitis (infection of the
colon).
C. difficile makes toxins that damage the cells that line the colon. The study doctors want
to find out how these toxins cause damage to the cells in the colon.
The purpose of this study is to examine pathogenic mechanisms of Clostridium difficile
toxin-mediated intestinal injury and inflammation. Two primary mechanisms will be examined.
- To examine the hypothesis is that microRNA expression profiles are dysregulated by
Clostridium difficile toxin exposure and that dysregulation of miRNA expression plays a
role in the pathogenesis of C. difficile associated diseases.
- To examine the hypothesis is that the TLR9 receptor mediates key inflammatory events in
response to Clostridium difficile toxin exposure.
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