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Clinical Trial Summary

This is an open-label, multicenter, phase 1b/2 trial of IMM01 (SIRPĪ± Fc) plus tislelizumab in patients with advanced solid tumors and lymphomas.


Clinical Trial Description

This open-label, multicenter, phase 1b/2 trial is conducted to evaluate the safety, tolerability and preliminary activity in patients with advanced solid tumors and lymphomas. This trial includes two parts: the phase 1b dose escalation part and the phase 2 dose expansion part. In the dose escalation part with a standard 3+3 design, IMM01 (1.0, 1.5, 2.0 mg/kg) was administered once a week and tislelizumab (200mg) was administered once every 3 weeks. In the dose expansion part, IMM01 (the dose determined in the dose escalation part) was administered once a week and tislelizumab (200mg) was administered once every 3 weeks. And the cohorts includes HNSCC, NSCLC, SCLC, R/R cHL and others. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05833984
Study type Interventional
Source ImmuneOnco Biopharmaceuticals (Shanghai) Inc.
Contact Zhenzhen Zong
Phone 86-21-38016387
Email zhenzhen.zong@immuneonco.com
Status Recruiting
Phase Phase 1/Phase 2
Start date May 17, 2022
Completion date November 20, 2024

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