CKD Clinical Trial
Official title:
Screening of Gastrointestinal Tract Bleeding Causes Among Chronic Renal Failure Patients in Assuit University in a Single Study Center
The aim of the current study is to screen different causes and characteristics of Gastrointestinal bleeding in Chronic Renal Failure patients at Assuit University Hospital according to their stages based on e GFR (Stage I to IV), in order to assess different modalities of therapeutic intervention from medical therapy up to therapeutic intervention.
Status | Not yet recruiting |
Enrollment | 100 |
Est. completion date | December 1, 2021 |
Est. primary completion date | October 1, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - One hundred Chronic Renal Failure patients with different stages (stage I to IV) according to the National Kidney Foundation are recruited from inpatients of renal unit in internal medicine department, Assuit university hospitals. Their GFR will assessed by using Chronic Renal Failure EPI equation measured as GFR=166 x(s cr/0.7)-1.209X(0.993)age if female, and GFR=163X(s cr/0.9)-1.209x(0.993)age if male. (Andrews et al 2008). Chronic Renal Failure staging according to GFR by Chronic Renal Failure EPI is: - Stage1 in which GFR>90 mil/min but evidence of kidney damage. - Stage 2 GFR 60-89 mil/min. - Stage 3 GFR 30-95 mil/min. - Stage 4 GFR 15-29 mil/min. - Stage 5 GFR<15 mil/min. Exclusion Criteria: - All Patients with local causes of Gastrointestinal Bleeding - Benign and Malignant tumors in Gastrointestinal Tract. - Patients with Hemorrhoids or anal fissures. - Patients with Mallory-Weiss tears. - patients with Diverticular disease. - patients with Colon polyps. - patients with infectious causes of GIT bleeding (Salmonella, Shigella) - patients with Angiodysplasia. - patients with Esophageal varices |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Assiut University |
Barkun AN, Bardou M, Kuipers EJ, Sung J, Hunt RH, Martel M, Sinclair P; International Consensus Upper Gastrointestinal Bleeding Conference Group. International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med. 2010 Jan 19;152(2):101-13. doi: 10.7326/0003-4819-152-2-201001190-00009. — View Citation
Ishigami J, Matsushita K. Clinical epidemiology of infectious disease among patients with chronic kidney disease. Clin Exp Nephrol. 2019 Apr;23(4):437-447. doi: 10.1007/s10157-018-1641-8. Epub 2018 Sep 3. Review. Erratum in: Clin Exp Nephrol. 2019 Mar 2;:. — View Citation
Kim BS, Li BT, Engel A, Samra JS, Clarke S, Norton ID, Li AE. Diagnosis of gastrointestinal bleeding: A practical guide for clinicians. World J Gastrointest Pathophysiol. 2014 Nov 15;5(4):467-78. doi: 10.4291/wjgp.v5.i4.467. Review. — View Citation
Stevens PE, Levin A; Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group Members. Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Ann Intern Med. 2013 Jun 4;158(11):825-30. doi: 10.7326/0003-4819-158-11-201306040-00007. — View Citation
Zuccaro G Jr. Management of the adult patient with acute lower gastrointestinal bleeding. American College of Gastroenterology. Practice Parameters Committee. Am J Gastroenterol. 1998 Aug;93(8):1202-8. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Assessment of different modalities of therapeutic intervention. | medical therapy up to therapeutic intervention data will be received. | one year from October 2020 to October 2021 |
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