Cirrhosis Clinical Trial
Official title:
Feeding Behavior and Taste Sensitivity Before and After Liver or Renal Transplantation
This study evaluates the influence of the taste sensitivity, of food preferences and of the reward system on the energetic balance before and after liver transplantation in cirrhotic patients and after kidney transplantation in renal failure patients
Background and Aims: Protein-energy malnutrition is associated to cirrhosis with a high
prevalence and greatly increases the morbidity and mortality of the disease. Malnutrition
results of numerous causes including intestinal malabsorption, increased energy resting
expenditure, metabolism disturbances, impaired sensory taste and changes in food preferences
which might participate to a reduction in food intake. The aim of this study was to determine
the relationships that may exist between taste sensitivity and food preferences on the one
hand, eating habits, nutritional status, energy balance and biological parameters including
amino acids on the other hand in patients with end-stage cirrhosis and in patients with renal
failure.
Fifteen end-stage cirrhotic patients and 15 renal failure patients will be included and
matched with 30 healthy subjects. The following parameters will be evaluated during a morning
testing session: gustatory sensitivity using a triangular detection threshold method for
sweet, salty and umami solutions; preferences for fat- and carbohydrate-rich foods using the
PrefQuest score; liking for six foods (protein-, carbohydrate- and fat-rich foods) and
wanting for 18 foods (photographs); hunger sensation; energy intake (24 h ingested food);
body composition (BMI and impedancemetry); resting energy expenditure (indirect calorimetry)
and physical activity (questionnaire). Several plasmatic parameters (amino-acids, leptin,
ghrelin, lipid profile) will be also determined.
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