Cirrhosis Clinical Trial
The investigators conducted a pilot study including 17 patients with liver cirrhosis showing that a moderate exercise programme during three months increased thigh circumference,exercise tolerance and quality of life without adverse effects. The present study aim to more accurately evaluate the effect of exercise on muscle mass, effort tolerance and inflammatory response in patients with cirrhosis. This study will include 30 patients with compensated liver cirrhosis that will be randomized into two groups: exercise group and control group. Evaluation of muscle mass, effort tolerance, inflammatory response and quality of life will be made at the beginning and at the end of the study.
Exercise group: will do a physiotherapist supervised exercise programme 1 hour three times
per week during three months and relaxation after exercise. Control group: only relaxation 1
hour three times per week during three months.
Assessment: clinical and laboratory examinations performed at baseline and at the end of the
study. The investigators will analyze the changes in muscle mass by anthropometric
measurements and advanced techniques (CT scan, densitometry), effort tolerance (stress
test), quality of life (sF-36), glutamine synthetase activity in blood, oxidative damage and
inflammatory response. The investigators will analyze the survival and complications of
cirrhosis during the study and follow-up.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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