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NCT00424957 Clinical Trial

Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System

Cirrhosis Clinical Trial

Official title:
Brain Energy Metabolism in Patients With Acute Hepatic Encephalopathy Measured With PET

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00424957
Other study ID # 20060120
Secondary ID
Status Completed
Phase N/A
First received January 19, 2007
Last updated February 4, 2009
Start date November 2006
Est. completion date October 2008

Study information
Verified date February 2009
Source University of Aarhus
Contact n/a
Is FDA regulated No
Health authority Denmark: Ethics CommitteeDenmark: The Danish National Committee on Biomedical Research EthicsDenmark: Danish Dataprotection Agency
Study type Observational

Clinical Trial Summary

The purpose of the current study is to look into the pathogenesis of a severe medical condition causing acute episodes on the central nervous system as seen in majority of patients with liver cirrhosis.

Recruitment information / eligibility
Status Completed
Enrollment 18
Est. completion date October 2008
Est. primary completion date April 2007
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 45 Years to 65 Years
Eligibility Inclusion Criteria:

- 6 patients with liver cirrhosis with an acute episode of hepatic encephalopathy,

- 6 patients with liver cirrhosis without an acute episode of hepatic encephalopathy,

- 6 healthy subjects age and sex matched

Exclusion Criteria:

- Neurological and/or psychiatric condition,

- Non-treated diabetes,

- Pregnancy/breast-feeding

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Locations
Country Name City State
Denmark PET Centre, Aarhus University Hospital Aarhus

Sponsors (1)
Lead Sponsor Collaborator
University of Aarhus

Country where clinical trial is conducted

Denmark, 

References & Publications (1)

Ott P, Clemmesen O, Larsen FS. Cerebral metabolic disturbances in the brain during acute liver failure: from hyperammonemia to energy failure and proteolysis. Neurochem Int. 2005 Jul;47(1-2):13-8. Review. — View Citation

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