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Cicatrix clinical trials

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NCT ID: NCT06171386 Not yet recruiting - Scar Clinical Trials

Microneedling vs Dermabrasion for Early Facial Scar Resurfacing

Start date: June 2024
Phase: N/A
Study type: Interventional

This study aims to determine whether microneedling or dermabrasion in the early post-operative period is superior in improving the appearance of surgical scars on the face.

NCT ID: NCT06114394 Not yet recruiting - Cicatrization Clinical Trials

Complications Related to Palatal Graft Harvesting

Start date: October 30, 2023
Phase: N/A
Study type: Interventional

Soft tissue defects can be a problem, especially in patients with high smile lines; in these clinical scenarios, the treatment with periodontal plastic surgery in combination with the use of a connective tissue graft (CTG) is considered the gold-standard procedure. Single incision technique (Huerzeler & Weng, 1999) is one of the suggested procedures to harvest the CTG from palate. The UPV/EHU technique (Aguirre-Zorzano et al, 2017) showed less inflammation and post-surgical complications than trap-door technique, but also other technique should to be analysed. However, there is still no consensus about which is the best technique to obtain this kind of graft. Therefore, clinicians should justify their choice based on the tissue's quality obtained and the patient's well-being, producing the least number of complications, such as inflammation, post-surgical pain, or recession in the donor area. HYPOTHESIS: Does the technique of obtaining an CTG of the palate using the "UPV/EHU technique" (Aguirre-Zorzano et al., 2017) result in a lower number of complications versus the "single incision technique" (Huerzeler & Weng, 1999)? OBJECTIVES The main objective is to assess whether the complications occurring with the harvesting of the CTG using the "UPV/EHU technique" (Aguirre-Zorzano et al., 2017) are lower than with the "single incision technique"(Huerzeler & Weng, 1999), knowing the patient's perception of pain. The secondary objectives are: a) necrosis of the palate, b) possible resulting recession in the donor area, and c) characteristics of the graft obtained

NCT ID: NCT05672563 Not yet recruiting - Uterus; Scar Clinical Trials

Cesarean Scar Evaluation Using Saline Infusion Sonography in Women With Previous Pregnancy in Scar

Start date: February 1, 2023
Phase: N/A
Study type: Interventional

Evaluation of cesarean scar using saline-infused sonography in women with history of cesarean scar pregnancy.

NCT ID: NCT05470322 Not yet recruiting - Clinical trials for Hidradenitis Suppurativa

Efficacy and Tolerability of a Fractional Ablative Erbium Laser for Axillary Scarring for Hidradenitis Suppurativa Patients

Start date: July 2024
Phase: N/A
Study type: Interventional

Single center, open-label, baseline-controlled study evaluating the use of a Sciton fractionated ablative laser in the treatment of Hidradenitis Suppurativa (HS) scarring.

NCT ID: NCT05067309 Not yet recruiting - Clinical trials for Termination of Early Pregnancy in Scarred Uterus

Termination of Early Pregnancy in Scarred Uterus With Lletrozole and Misoprostol Compared to Misoprostol Alone

Start date: October 1, 2021
Phase:
Study type: Observational

Termination of early pregnancy in scarred uterus with letrozole and misoprostol compared to Misoprostol alone

NCT ID: NCT04997863 Not yet recruiting - Wound Clinical Trials

Clinical Efficacy and Safety of Sericin Hydrogel Sheet Impregnated With Bird's Nest Extract

Start date: November 1, 2021
Phase: N/A
Study type: Interventional

Split-thickness skin graft (STSG) is one of the most common procedures performed in plastic surgery and dermatology. The donor site of skin grafting is expected to heal without scarring. However, hypertrophic scar formation is prevalent among STSG donor sites during scar maturation and has become a significant problem at present. Hypertrophic scar results in aesthetic, physical, functional, and psychological problems, leading to a dramatic impact on patients' quality of life ultimately. There are many current therapeutic approaches for preventing and treating hypertrophic scars; however, they remain clinically unsatisfactory because many treatments have been associated with high recurrent rates, high cost, and side effects. Currently, there are no gold standards for hypertrophic scar therapy. There are many attempts to develop new treatment options for the prevention and management of scarring that are acceptable to both physicians and patients. It has previously been shown that both edible bird's nest (EBN) extract and sericin have effectiveness in reducing scar development. They might be a suitable alternative option for scar prevention and could be used safely. Therefore, the sericin hydrogel sheet impregnated with EBN extract is developed as it is believed that the synergism of these combined compounds would be a great help to prevent the development of scars. This study aims to evaluate the efficacy and safety of sericin hydrogel sheet impregnated with EBN extract for the prevention of scar formation in patients with STSG donor sites.

NCT ID: NCT04995302 Not yet recruiting - Burn Scar Clinical Trials

Microneedling Therapy With or Without Amnion Bilayer Sheeting on Scar Tissue

Start date: September 1, 2021
Phase: N/A
Study type: Interventional

The aim of this study is to compare the outcome of microneedling therapy with or without amnion bilayer sheeting on post-burn hypertrophic scar tissue. A clinical trial will be conducted with 17 samples, from September to December 2021.

NCT ID: NCT04928443 Not yet recruiting - Surgical Scar Clinical Trials

The Management of Surgical Scars Around Knee After Pediatric Orthopedic Surgery: an Observational, Case-control Study

Start date: August 15, 2021
Phase:
Study type: Observational

Scar is an unpleasant symptom that commonly appear after orthopedic surgery, especially the joint procedure. Due to the wide motion range, skin around joint has excessive tension that may increase risk for wide or conspicuous scar formation of surgical wound. Noticeable scar can negatively impact the quality of life and psychosocial development. However, scar management is overlooked in early recovery period easily. Patients commonly start to turn their attention to the surgical scar after the completion of rehabilitation or the resolution of disease or unbearable symptom. It is always beyond the best period of scar treatment, 3 to 6 months after wound healing. This study is aimed to observe and evaluate the scar formation with or without aggressive management in pediatric population within 6 months after wound healing.

NCT ID: NCT04593706 Not yet recruiting - Keloid Clinical Trials

Comparison of the Efficacy of Different Steroids in the Treatment of Abnormal Scars (Keloids, Hypertrophic Scars)

Start date: November 1, 2020
Phase: N/A
Study type: Interventional

Comparison of the Efficacy of Different Steroids in the Treatment of Abnormal Scars (Keloids and hypertrophic Scars)

NCT ID: NCT04233320 Not yet recruiting - Cicatrix Clinical Trials

Efficacy and Safety of Silicone Cream Containing Allium Cepa Extract

Start date: February 1, 2020
Phase: N/A
Study type: Interventional

The objectives of this study were to evaluate efficacy and safety of silicone cream containing Allium Cepa extract in post-cesarean surgical scars treatment. Post-cesarean surgical scars were equally seperated into 2 parts (left part and right part). Silicone cream containing Allium Cepa extract or commercial scar gel was ramdomly assigned to apply on left part or right part of the scar. They will be applied 2 times per day (morning and evening) for 3 months. Patient and Observer Scar Assessment Scale (POSAS) , Vancouver scar scale (VSS), melanin index, and erythema index (using cutometer) were used for scar evaluation at 0, 1,2,and 3 months. Moreover, adverse effects were also observed.