Chronic Rhinosinusitis Clinical Trial
Official title:
Chronic Rhinosinusitis in a Danish Population: Evaluation of Causes of Disease, Progress and Treatment
Introduction: Chronic Rhinosinusitis (CRS) is defined as inflammation of the nose and the
paranasal sinuses. It is a very common disorder increasing in both incidence and prevalence
with significant impact on quality of life and substantial health care costs. In this study
we evaluate the prevalence of CRS in Denmark and there is a need for consensus about
diagnosing this disease. Different questionnaires and different tests used for examination
are evaluated together with the patients compliance and days lost through illness.
Methods: As part of Ga2len (Global Asthma and Allergy European Network) a questionnaire on
CRS was posted to 5000 residents on Funen. From the completed and returned questionnaires
self reported CRS was evaluated. Respondents were invited for clinical examination including
spirometry, skin prick test, bloodsample and an ENT examination including nasal endoscopy,
acoustic rhinometry, peak nasal inspiratory flow and smell test. Questionnaire on quality of
life (EQ-5D) and symptom severity (SNOT-22) was completed. Medical diagnosed CRS was
diagnosed according to the definition on CRS stated by EPOS (European Position Paper on
Rhinosinusitis and Nasal Polyps 2007). CRS is defined as inflammation in the nose and
paranasal sinus and should be characterized by two or more symptoms one of which should be
either nasal blockage/obstruction/congestion or nasal discharge, +/- facial pain/pressure,
+/- reduction or loss of smell. Endoscopic signs should be present and symptoms must have
been present > 12 weeks. Patients diagnosed with CRS were invited for a 1 year and 2 year
follow up where examination and questionnaires were repeated and treatment compliance and
days lost through illness were evaluated.
n/a
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04131686 -
NAC Inhalation in the Treatment Of Symptomatic acuTe rhinosinUSitis
|
||
| Completed |
NCT02692794 -
Large Scale Cerebral Oximetry During Sinus Endoscopy
|
N/A | |
| Completed |
NCT01988779 -
Oral Versus Topical Antibiotics for Chronic Rhinosinusitis Exacerbations
|
Phase 3 | |
| Completed |
NCT01254916 -
The Sinonasal Outcome Test - 22, Validated for Danish Patients
|
N/A | |
| Completed |
NCT03614923 -
Etokimab in Adults With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
|
Phase 2 | |
| Completed |
NCT03781804 -
Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis With or Without the Presence of Nasal Polyps
|
Phase 3 | |
| Completed |
NCT01198912 -
Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With and Without Nasal Polyposis: a Double-blind Randomized Placebo-controlled Trial
|
Phase 2 | |
| Active, not recruiting |
NCT06457100 -
Esmolol Versus Lidocaine on the Quality of Postoperative Recovery in Patients Undergoing Functional Endoscopic Sinus Surgery
|
Phase 1/Phase 2 | |
| Completed |
NCT03280537 -
A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitus With Nasal Polyps
|
Phase 3 | |
| Terminated |
NCT02285283 -
Itraconazole for Fungal Sensitive Chronic Rhinosinusitis With Nasal Polyps
|
Phase 2/Phase 3 | |
| Completed |
NCT02307825 -
Azithromycin for Patients With Chronic Rhinosinusitis Failing Medical and Surgical Therapy
|
Phase 4 | |
| Completed |
NCT02218307 -
The Use of Antibiotic Sinonasal Rinse After Sinus Surgery
|
Phase 4 | |
| Recruiting |
NCT01024075 -
Effect of Sinufoam-Dexamethasone Mixture on Post Endoscopic Sinus Surgery Outcomes
|
Phase 4 | |
| Completed |
NCT01002313 -
Effect of Prednisone onTregs and TH17
|
Phase 1 | |
| Completed |
NCT00396162 -
Use of Probiotics as Adjunctive Treatment for Chronic Rhinosinusitis
|
Phase 4 | |
| Completed |
NCT03280550 -
A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps
|
Phase 3 | |
| Recruiting |
NCT05935683 -
Rhinosinusitis Italian Network: the Italian Registry for Severe, Uncontrolled Chronic Rhinosinusitis
|
||
| Completed |
NCT03478930 -
An Extension Study of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps
|
Phase 3 | |
| Completed |
NCT01943370 -
Early Saline Irrigation to Decrease Post-operative Endoscopic Debridement
|
N/A | |
| Completed |
NCT02154555 -
A Randomized Controlled Trial Evaluating Postoperative Debridement Following Endoscopic Sinus Surgery
|
N/A |