Chronic Rhinosinusitis Clinical Trial
Official title:
Subcutaneous Omalizumab for Treatment of Chronic Rhinosinusitis With Nasal Polyposis
The investigators are doing this research study to learn more about a drug called Xolair (omalizumab). The investigators want to see if it is an effective treatment for chronic rhinosinusitis (CRS). Specifically, the investigators want to see whether Xolair will make nasal polyps smaller and less thick, and relieve symptoms in people with CRS. Polyps are abnormal growths of tissue that can grow in the lining of your sinuses (the inside of your nose). The investigators also want to find out if it is safe to use (whether it causes side effects).
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04131686 -
NAC Inhalation in the Treatment Of Symptomatic acuTe rhinosinUSitis
|
||
| Completed |
NCT02692794 -
Large Scale Cerebral Oximetry During Sinus Endoscopy
|
N/A | |
| Completed |
NCT01988779 -
Oral Versus Topical Antibiotics for Chronic Rhinosinusitis Exacerbations
|
Phase 3 | |
| Completed |
NCT01254916 -
The Sinonasal Outcome Test - 22, Validated for Danish Patients
|
N/A | |
| Completed |
NCT03614923 -
Etokimab in Adults With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
|
Phase 2 | |
| Completed |
NCT03781804 -
Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis With or Without the Presence of Nasal Polyps
|
Phase 3 | |
| Completed |
NCT01198912 -
Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With and Without Nasal Polyposis: a Double-blind Randomized Placebo-controlled Trial
|
Phase 2 | |
| Active, not recruiting |
NCT06457100 -
Esmolol Versus Lidocaine on the Quality of Postoperative Recovery in Patients Undergoing Functional Endoscopic Sinus Surgery
|
Phase 1/Phase 2 | |
| Completed |
NCT03280537 -
A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitus With Nasal Polyps
|
Phase 3 | |
| Terminated |
NCT02285283 -
Itraconazole for Fungal Sensitive Chronic Rhinosinusitis With Nasal Polyps
|
Phase 2/Phase 3 | |
| Completed |
NCT02307825 -
Azithromycin for Patients With Chronic Rhinosinusitis Failing Medical and Surgical Therapy
|
Phase 4 | |
| Completed |
NCT02218307 -
The Use of Antibiotic Sinonasal Rinse After Sinus Surgery
|
Phase 4 | |
| Recruiting |
NCT01024075 -
Effect of Sinufoam-Dexamethasone Mixture on Post Endoscopic Sinus Surgery Outcomes
|
Phase 4 | |
| Completed |
NCT01002313 -
Effect of Prednisone onTregs and TH17
|
Phase 1 | |
| Completed |
NCT00396162 -
Use of Probiotics as Adjunctive Treatment for Chronic Rhinosinusitis
|
Phase 4 | |
| Completed |
NCT03280550 -
A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps
|
Phase 3 | |
| Recruiting |
NCT05935683 -
Rhinosinusitis Italian Network: the Italian Registry for Severe, Uncontrolled Chronic Rhinosinusitis
|
||
| Completed |
NCT03478930 -
An Extension Study of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps
|
Phase 3 | |
| Completed |
NCT01943370 -
Early Saline Irrigation to Decrease Post-operative Endoscopic Debridement
|
N/A | |
| Completed |
NCT02154555 -
A Randomized Controlled Trial Evaluating Postoperative Debridement Following Endoscopic Sinus Surgery
|
N/A |