Chronic Rhinitis Clinical Trial
Official title:
To Elucidate the Epidemiological, Clinical, and Intrinsic Characteristics of Chronic Rhinitis
Chronic rhinitis affects 10-40% of China's population, or over 300 million people, and can lead to respiratory and psychological issues. Despite treatment progress, 30% of patients have poor outcomes, likely due to the disease's complexity and a lack of new treatment targets. The incidence is rising, but there's a lack of nationwide studies on its variations. This study addresses this through a multicentric survey to create a national database on chronic rhinitis, including epidemiological, clinical, and biological data. The goal is to understand chronic rhinitis's causes and risks, improve treatments, and develop preventive strategies. The study will survey 30,000 patients across China, using questionnaires and nasal exams, and preserve biological samples in a biobank for detailed analysis. This will lay the groundwork for understanding the disease's mechanisms, developing new diagnostics, and tailoring prevention and treatment approaches for different forms of chronic rhinitis.
Status | Not yet recruiting |
Enrollment | 150000 |
Est. completion date | August 1, 2027 |
Est. primary completion date | May 1, 2027 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility | Inclusion Criteria: Chinese aged between 18 and 70 years old who have resided at the survey site for more than 6 months within the 12 months preceding the survey. Exclusion Criteria: 1. Have undergone sinus or nasal surgery, or have been diagnosed with sinusitis, nasal polyps, or benign or malignant tumors of the nasal cavity and paranasal sinuses within the past 12 months. 2. Have a medical history of primary cystic fibrosis or immotile cilia syndrome. 3. Reside in specialized functional areas such as industrial workshops, military bases, student dormitories, nursing homes, or similar environments that may confound the study results. 4. Have a mental disorder or cognitive impairment that could affect their ability to participate in the study, including but not limited to dementia, comprehension disorders, deafness, mutism, etc. |
Country | Name | City | State |
---|---|---|---|
China | Tongji Hosptial affiliated to Tongji Medical college of Huazhong University of Science and Technology | Wuhan | Hubei |
Lead Sponsor | Collaborator |
---|---|
Zheng Liu ENT | First Affiliated Hospital of Chongqing Medical University, First Affiliated Hospital of Xinjiang Medical University, Hainan People's Hospital, Peking Union Medical College, Shandong Second Provincial General Hospital |
China,
Makar AB, McMartin KE, Palese M, Tephly TR. Formate assay in body fluids: application in methanol poisoning. Biochem Med. 1975 Jun;13(2):117-26. doi: 10.1016/0006-2944(75)90147-7. No abstract available. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The prevalence and distribution patterns of chronic rhinitis within the Chinese population | To comprehensively understand the prevalence and distribution of chronic rhinitis within the Chinese population, the study aims to investigate: The overall prevalence of chronic rhinitis, as well as its incidence across various age groups; The specific types of chronic rhinitis, including allergic rhinitis, local allergic rhinitis, Non-Allergic Rhinitis with Eosinophilia Syndrome (NARES), and Intrinsic Rhinitis (IR), with a focus on their individual incidences; The associations between chronic rhinitis and environmental factors, personal occupation, genetic predisposition, disease severity, diagnostic and treatment methods, disease control, and related comorbidities. |
2024.04-2025.04 | |
Primary | The clinical features and endotype of chronic rhinitis | The endotype of chronic rhinitis was conducted based on proteomic analyses of peripheral blood, serum, and/or nasal mucosal epithelial cells, in conjunction with epidemiological data and clinical classifications provided by nasal examination. | 2024.04-2026.04 |
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