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Defining a PK and PD Model for Peripheral Analgesia After IV Oxytocin

Chronic Pain Clinical Trial

Official title:
Defining a Pharmacokinetic and Pharmacodynamic Model for Peripheral Analgesia After Intravenous Oxytocin

Clinical Trial Summary

The goal of this clinical trial is to learn about oxytocin ( a naturally occurring hormone made in the brain that transmits messages) and the effects it may have on thermal heat pain after intravenous administration. The main question it aims to define is the time course of change in pain score after a 5 minute heating of the skin administered at intervals during and following infusion of intravenous oxytocin in order to create a Pharmacokinetic and a Pharmacodynamic model for oxytocin-induced analgesia. Participants will be asked to rate thermal heat temperatures before, during and after the intravenous infusion of oxytocin.

Clinical Trial Description

The primary objective is to define the time course of change in pain score after a 5 minute heating of the skin applied at intervals during and following infusion of intravenous oxytocin in order to create a Pharmacokinetic and Pharmacodynamic model for oxytocin-induced analgesia. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05929339
Study type Interventional
Source Wake Forest University Health Sciences
Contact Regina Curry, RN
Phone 336-716-4294
Email recurry@wakehealth.edu
Status Recruiting
Phase Phase 2
Start date August 17, 2023
Completion date December 2024
View Details
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