Chronic Pain Clinical Trial
Official title:
Beneficial Effects of Self-hypnosis/Self-care Learning Program for Chronic Pain Patients : a MRI and EEG Study
Chronic pain concerns one in four adults in Belgium. Fibromyalgia is an example of chronic
pain and is characterized by diffused and migrant musculo-tendinous pain localized in the
limbs and at an axial level. The technological improvement in neuroimaging allowed to
improve, at a cerebral level, the identification of the structural and the functional
characteristics of this clinical entity. Studies indicated a modification in cerebral
morphometry showing an alteration of white and grey matter in the anterior cingulate cortex,
orbitofrontal lateral cortex, cerebellum, basal ganglia, insula, secondary somatosensory
cortex, thalamus, amygdala, putamen, superior temporal gyrus and periaqueductal grey matter.
At a functional level, studies show un alteration in the connectivity of the default mode
network, an atrophy of zones implicated in nociception and an increased activation of zone
implicated in response to a nociceptive stimulus.
Nowadays, researchers are interested in finding out the beneficial effects of
non-pharmacological techniques to improve de well-being of patients with chronic pain.
Hypnosis is one of these techniques that has already proven to be successful in decreasing
pain and improving global quality of life. Nevertheless, to our knowledge, no study has been
conducted to understand the impact of hypnosis upon the cerebral functioning of these
patients. Therefore, the aim of this study is to understand the impact of a 6 months
self-hypnosis/self-care learning program upon the structural and functional functioning of
the brain by means of functional magnetic resonance imagery (fMRI) and electroencephalography
(EEG).
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