Chronic Pain Clinical Trial
Official title:
A Single-site, Observational Cohort Study to Investigate Predictive Markers of the Effects of Opioid Therapy in Patients With Chronic Pain
Chronic pain is a significant problem for a large part of the adult population. Opioids are
the mainstay of therapy for moderate to severe pain because of their safety, multiple routes
of administration, reliability, and effectiveness for all types of pain. However, there is a
wide variation in treatment response and a high frequency of side effects associated with the
use of opioids. Thus it is important to identify patients who will experience successful pain
control with treatment. Unfortunately, as of today no robust objective measures exist for the
assessment of the pain-relieving effect of opioids. The pain treatment offered to any given
patient is thus largely dependent on the treating physician's experience and the primary pain
diagnosis, rather than the characteristics of the individual patient. Unfortunately, this
strategy often leads to inadequate treatment, side effects and distress. An implementable
clinical tool that can predict and distinguish successful pain control with opioid treatment
is therefore warranted.
Quantitative sensory testing (QST) is a method to evaluate the individual pain system. It has
been successfully used to describe the problems of individual variation in pain and to
predict and measure the responses to an intervention. The investigators recently examined how
advanced analyses of QST and pain-related catastrophic thinking could predict opioid response
in chronic pain patients whom had not previously received opioid treatment. This study showed
that the effect of opioid treatment was predicted by certain pain system responses,
catastrophic thinking related to pain and brainwave patterns. The investigators now want to
expand on this study by including all patients assigned to opioid treatment by their treating
physician. The investigators are also increasing their data collection and using a more
elaborate pain system characterization, investigating pain-relevant psychological factors and
sleep patter by questionnaires, socio-demographic parameters and collecting descriptive
genetic information.
The overall goal of the ABILITY-2 study is to help improve pain diagnostics and treatment by
developing an implementable algorithm based on individual patient characteristics to be used
in the clinic. The investigators hypothesize that successful pain control with opioids can be
predicted before treatment initiation with advanced analyses of QST, pain-related
psychological factors and socio-demographic data.
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