Fentanyl Sublingual Spray for the Treatment of Acute Procedure-related Pain in a Monitored Setting

Chronic Pain Clinical Trial

Official title:

A Pilot, Randomized, Double-blind, Placebo-controlled Single-center Study to Evaluate the Safety and Efficacy of SUBSYS™ (Fentanyl Sublingual Spray) for the Treatment of Acute Procedure-related Pain in a Monitored Setting

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT02138409
• Other study ID #: INS-13-021
• Status: Withdrawn
• Phase: Phase 3
• First received: May 12, 2014
• Last updated: January 2, 2018
• Start date: December 30, 2017
• Est. completion date: January 2018

Study information

• Verified date: January 2018
• Source: INSYS Therapeutics Inc
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Participants will be selected from patients who have been scheduled at the site for treatment of chronic pain without sedation. They will receive either fentanyl sublingual spray or a matching placebo sublingual spray that delivers no medication.

Participants may take pain killers at any time after the procedure for pain relief. They will be given a diary card, which they will take home. They will record the name of the medication taken, the time, and dosage.

The study coordinator will call participants about 24 hours after the procedure to collect information from the diary card and follow up information about pain and side effects (adverse events) after they left the site.

Description:

Participants will be separated into opioid-experienced and opioid-naïve groups. Participants in each group will be randomly allocated in a 3:1 ratio to receive fentanyl sublingual spray (FSS) or a matching placebo sublingual spray (PSS) 10 minutes before the scheduled procedure. Based on FDA guidelines, opioid-experienced FSS participants will receive FSS 400 µg, and opioid-naïve FSS participants will be further randomized in a 1:1 ratio to receive either 100 µg or 200 µg. All participants randomized to placebo receive the same matching PSS, regardless of opioid experience. Pain and sedation will be recorded multiple times during the scheduled procedure. If rescue medication is needed during the procedure, local anesthetic standard of care for the procedure will be administered and recorded in the study record. Efficacy and safety/tolerability of fentanyl sublingual spray will be evaluated among and between the treatment groups.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: January 2018
• Est. primary completion date: January 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Has scheduled an interventional procedure for treatment of pain without sedation

• Has cleared pre-operative assessment

• Is able to read or understand informed consent form, and gives consent to participate in the study

Exclusion Criteria:

• Is taking any form of fentanyl

• Has oral pathology that would prevent effective absorption of study medication

• Was treated with an investigational drug within protocol-specified parameters

• Has signs, symptoms or history of any condition that, per protocol or in the opinion of the investigator, might compromise: 1) the safety or well-being of the participant or study staff, 2) the safety or well-being of the participant's offspring (such as through pregnancy or breast-feeding), 3) the analysis of results

Related Conditions & MeSH terms

• Chronic Pain

Intervention

Drug:
• Fentanyl Sublingual Spray (FSS)
Fentanyl sublingual spray (FSS) packaged to deliver 100 µg/spray, 200 µg/spray or 400 µg/spray
• Placebo Sublingual Spray (PSS)
Placebo sublingual spray (PSS) packaged to match FSS, but deliver no drug

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
INSYS Therapeutics Inc

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Pain scored on a scale from 0 to 10, where 0 = no pain and 10 = the most intense pain imaginable		within 24 hours
Secondary	Sedation scored on a scale from 0 to 4, where 0 = awake/alert and 4 = unarousable		within 24 hours