Chronic Pain Clinical Trial
Official title:
Effect of Transcranial Magnetic Stimulation in the Cortical, Subcortical Neuromodulation and in Pain Threshold of Chronic Myofascial Pain Patients
The purpose of this study is to investigate if rTMS may have a positive impact on pain thresholds and cortical excitability in subjects with chronic musculoskeletal diseases of complex cranio-cervical-mandibular with myofascial component.
About 30% of the world population suffers from pain. These data demonstrate the great need
for research focusing on findings that contribute to the development of more
effectivetreatments for patients with chronic pain syndromesThe chronic pain can occur by
various means, either physical or psychological injuries. Above all, whatever its history,
its installation is due to mechanisms of neuroplasticity, in this case non-functional,
called maladaptive plasticity. This process and the symptoms associated with chronic pain
cause the treatment to be a challenge for health professionals. To obtain a positive result,
it is necessary to modulate all aspects involved in the processing of pain, including
functional retraining.
This study is a randomized, blinded, parallel medical trial, placebo-sham- controlled and
will be carried out int the Clinical Research Outpatient Clinic of the Hospital de Clínicas
de Porto Alegre (HCPA), with females, aged 19 to 65 years, who are limited in their ability
to perform active and routine activities due to MPS in the previous 3 months. We will test
the hypothesis that repetitive transcranial magnetic stimulation (rTMS) would be more
effective than a placebo-sham for the treatment of chronic MPS by pain score, cortical
excitability parameters, function of cortical-spinal modulatory system (CSMS), sleep quality
and serum BDNF.The participants will be randomized into the placebo-sham or rTMS treatment
groups for 10 consecutive sessions, at 10 Hz frequency. To assessment will be used the
visual analogue scale (VAS), Brazilian Profile of Chronic Pain: Screen (B-PCP:S),
quantitative sensory testing (QST), TMS parameters, (motor-evoked potential (MEP),
intracortical facilitation (ICF) ) and serum BDNF.
Through, these data will prompt us to investigate whether rTMS can be used as a therapeutic
option in short and long term in MPS. In this context, we will test the hypothesis that rTMS
would be more effective than a placebo-sham for the treatment of chronic MPS that determined
some disability. We also will teste whether rTMS would change induced changes in both
electrophysiological markers of LTP-like phenomena and in the levels of BDNF. Additionally,
we will assess whether the treatment induce changes on the cortical-spinal modulatory
system, as well if this effect would be associated with the inhibition or facilitation.
Finally, we will test whether rTMS would be more effective than a placebo-sham in improving
sleep quality.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT01659073 -
Using Perfusion MRI to Measure the Dynamic Changes in Neural Activation Associated With Caloric Vestibular Stimulation
|
N/A | |
Recruiting |
NCT05914311 -
Use of Dermabond in Mitigation of Spinal Cord Stimulation (SCS) Trial Lead Migration
|
N/A | |
Recruiting |
NCT05422456 -
The Turkish Version of Functional Disability Inventory
|
||
Enrolling by invitation |
NCT05422443 -
The Turkish Version of Pain Coping Questionnaire
|
||
Completed |
NCT05057988 -
Virtual Empowered Relief for Chronic Pain
|
N/A | |
Completed |
NCT04385030 -
Neurostimulation and Mirror Therapy in Traumatic Brachial Plexus Injury
|
N/A | |
Recruiting |
NCT06206252 -
Can Medical Cannabis Affect Opioid Use?
|
||
Completed |
NCT05103319 -
Simultaneous Application of Ketamine and Lidocaine During an Ambulatory Infusion Therapy as a Treatment Option in Refractory Chronic Pain Conditions
|
||
Completed |
NCT03687762 -
Back on Track to Healthy Living Study
|
N/A | |
Completed |
NCT04171336 -
Animal-assisted Therapy for Children and Adolescents With Chronic Pain
|
N/A | |
Completed |
NCT03179475 -
Targin® for Chronic Pain Management in Patients With Spinal Cord Injury
|
Phase 4 | |
Completed |
NCT03418129 -
Neuromodulatory Treatments for Pain Management in TBI
|
N/A | |
Completed |
NCT03268551 -
MEMO-Medical Marijuana and Opioids Study
|
||
Recruiting |
NCT06060028 -
The Power of Touch. Non-Invasive C-Tactile Stimulation for Chronic Osteoarthritis Pain
|
N/A | |
Recruiting |
NCT06204627 -
TDCS* and Laterality Trainnning in Patients With Chronic Neck Pain
|
N/A | |
Completed |
NCT05496205 -
A SAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers
|
Phase 1 | |
Completed |
NCT00983385 -
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking Either WHO Step I or Step II Analgesics or no Regular Analgesics
|
Phase 3 | |
Recruiting |
NCT05118204 -
Randomized Trial of Buprenorphine Microdose Inductions During Hospitalization
|
Phase 4 | |
Terminated |
NCT03538444 -
Repetitive Transcranial Magnetic Stimulation for Opiate Use Disorder
|
N/A | |
Not yet recruiting |
NCT05812703 -
Biometrics and Self-reported Health Changes in Adults Receiving Behavioral Treatments for Chronic Pain
|