Chronic Pain Clinical Trial
Official title:
Effect of Paracetamol on the Status in Glutathione for the Aged Person
Paracetamol is one of the most widely used analgesics in the world especially for chronic
pain in the elderly. The metabolism of paracetamol occurs in the liver and involves the use
of glutamyl-cysteinyl-glycine (Glutathione (GSH)). Medications such as paracetamol, may
reduce the reserves of GSH because it is used for detoxification and elimination. It is well
known that the concentration of GSH decrease after administration of paracetamol in humans
and animals.
Aging is associated with decreased concentration of GSH in cells and tissues. In the
elderly, a decrease of GSH concentration in plasma or red blood cells is associated with
decreased physical and mental health.
We wish here to determine, in subjects aged over 70 years, the blood concentration of
glutathione (GSH) and urinary loss of cysteine in the detoxification of paracetamol, when
taking paracetamol treatment repeated.
Paracetamol is one of the most widely used analgesics in the world especially for chronic
pain in the elderly. The metabolism of paracetamol occurs in the liver and involves the use
of glutamyl-cysteinyl-glycine (glutathione (GSH)). Medications such as paracetamol, may
reduce the reserves of GSH because it is used for detoxification and elimination. It is well
known that the concentration of GSH decrease after administration of paracetamol in humans
and animals.
Aging is associated with decreased concentration of GSH in cells and tissues. In the
elderly, a decrease of GSH concentration in plasma or red blood cells is associated with
decreased physical and mental health.
We wish here to determine, in subjects aged over 70 years, the blood concentration of
glutathione (GSH) and urinary loss of cysteine in the detoxification of paracetamol, when
taking paracetamol treatment repeated.
;
Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01659073 -
Using Perfusion MRI to Measure the Dynamic Changes in Neural Activation Associated With Caloric Vestibular Stimulation
|
N/A | |
| Recruiting |
NCT05914311 -
Use of Dermabond in Mitigation of Spinal Cord Stimulation (SCS) Trial Lead Migration
|
N/A | |
| Recruiting |
NCT05422456 -
The Turkish Version of Functional Disability Inventory
|
||
| Enrolling by invitation |
NCT05422443 -
The Turkish Version of Pain Coping Questionnaire
|
||
| Completed |
NCT05057988 -
Virtual Empowered Relief for Chronic Pain
|
N/A | |
| Completed |
NCT04385030 -
Neurostimulation and Mirror Therapy in Traumatic Brachial Plexus Injury
|
N/A | |
| Recruiting |
NCT06206252 -
Can Medical Cannabis Affect Opioid Use?
|
||
| Completed |
NCT05103319 -
Simultaneous Application of Ketamine and Lidocaine During an Ambulatory Infusion Therapy as a Treatment Option in Refractory Chronic Pain Conditions
|
||
| Completed |
NCT03687762 -
Back on Track to Healthy Living Study
|
N/A | |
| Completed |
NCT04171336 -
Animal-assisted Therapy for Children and Adolescents With Chronic Pain
|
N/A | |
| Completed |
NCT03179475 -
Targin® for Chronic Pain Management in Patients With Spinal Cord Injury
|
Phase 4 | |
| Completed |
NCT03418129 -
Neuromodulatory Treatments for Pain Management in TBI
|
N/A | |
| Completed |
NCT03268551 -
MEMO-Medical Marijuana and Opioids Study
|
||
| Recruiting |
NCT06204627 -
TDCS* and Laterality Trainnning in Patients With Chronic Neck Pain
|
N/A | |
| Recruiting |
NCT06060028 -
The Power of Touch. Non-Invasive C-Tactile Stimulation for Chronic Osteoarthritis Pain
|
N/A | |
| Completed |
NCT05496205 -
A SAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT00983385 -
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking Either WHO Step I or Step II Analgesics or no Regular Analgesics
|
Phase 3 | |
| Recruiting |
NCT05118204 -
Randomized Trial of Buprenorphine Microdose Inductions During Hospitalization
|
Phase 4 | |
| Terminated |
NCT03538444 -
Repetitive Transcranial Magnetic Stimulation for Opiate Use Disorder
|
N/A | |
| Not yet recruiting |
NCT05812703 -
Biometrics and Self-reported Health Changes in Adults Receiving Behavioral Treatments for Chronic Pain
|