Chronic Lymphocytic Leukemia Clinical Trial
Official title:
A Phase 2 Clinical Trial To Evaluate Lenalidomide And Obinutuzumab For The Treatment Of Patients With Not Previously Treated Chronic Lymphocytic Leukemia
This is phase 1/2 study for patients with CLL or (SLL) who have not been previously treated. This study will evaluate whether obinutuzumab and lenalidomide is safe and tolerable in this setting and induce complete clinical responses.
This is phase 1/2 study for patients with CLL or (SLL) who have not been previously treated.
The primary endpoint is to determine safety and tolerability of the regimen and determine
complete response (CR) to therapy. The secondary endpoints will assess the impact of
treatment on progression free and overall survival
Eligible patients will receive obinutuzumab for 6 x 28 day cycles. Patients will also receive
lenalidomide orally once daily on days 8-28 of each 28 day cycles. The starting dose for all
patients is 5 mg PO daily. At the start of each cycle, there is intra-patient dose-escalation
to a maximum of 25mg daily, as tolerated.
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