Chronic Liver Disease Clinical Trial
Official title:
Evaluation of Blood Ammonia Level as a Non Invasive Predictor for Presence of Gastroesophageal Varices and Risk of Bleeding
Assessment of blood ammonia level as a non-invasive predictor for presence of EV and risk of bleeding
A prospective cross sectional study on 150 consecutive patients screening for esophageal
varices.
Patient groups groups:
Group (1): 100 patients with esophageal varices
Group (2): 50 chronic liver disease patients with no esophageal varices as a control group.
All patients will be subjected to:
1. - Detailed history-taking
2. - Full clinical examination
3. - Laboratory investigations:
- Complete blood picture (CBC)
- Erythrocyte sedimentation rate (ESR)
- Renal function tests
- Liver function tests
- Prothrombin time and activity
- Viral markers (HCV Ab - HBV Ag)
- Blood ammonia level.
4. - Pelviabdominal US: Ultrasound examination of the liver, portal venous system, spleen,
kidney and other abdominal organs.
5. - Upper GITendoscopy:
- Varices will be classified according to the Japanese classification 1996,
- The Baveno 11 score will be used to differentiate between mild and severe portal
hypertensive gastropathy.
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