Clinical Trials Logo

Clinical Trial Summary

Introduction: Chronic kidney disease is characterized by a progressive deterioration of renal function. At the end of the progression, when complications occur (overhydration, electrolyte imbalances or retention of uremic toxins), a percentage of patients requiring renal replacement therapy (haemodialysis). When starting the haemodialysis, the patient holds the residual renal function (RRF) which is lost over time. To preserve the RRF, the patient is treated with diuretics loops and / or thiazide diuretics. The effect of this treatment is lost when renal function worsens. In this context, there are few studies that explore the use and effectiveness of diuretics in patients on haemodialysis 2. Objectives and Hypothesis:

Hypothesis: The treatment with furosemide and hydrochlorothiazide in haemodialysis patients with RRF could:

- To decrease in weight gain between haemodialysis sessions.

- To increase urine volume.

- To decrease the ultrafiltration in haemodialysis sessions ( the long interdialytic interval)

Main Objective:To asses the effect of combined hydrochlorothiazide-furosemide therapy on gain weight between haemodialysis sessions in patients with RRF

Secondary Objective: To asses the effect of combined hydrochlorothiazide-furosemide therapy on dialytic, clinical and analytical variables and use of the antihypertensive treatment

3. Methodology: Randomized open clinical trial to compare the effectiveness of the administration of diuretics in haemodialysis patients with residual renal function in single centre.

The population of study are patients with chronic renal disease in haemodialysis therapy that they preserve residual renal function ( more 200ml daily of urine). It will be a simple randomization, to asses the effect of combined hydrochlorothiazide-furosemide therapy

After a of 15 days washout without diuretic treatment, patients will be randomized to receive or not receive combined diuretic treatment for 1 month. After a 1 month washout , the patients will be receive or not the treatment according to cross over trial.


Clinical Trial Description

n/a


Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT01977430
Study type Interventional
Source Corporacion Parc Tauli
Contact Mabel - Bolos-Contador, MD
Phone 0034 937231010
Email mabeline17@hotmail.com
Status Recruiting
Phase Phase 4
Start date November 2013
Completion date March 2015

See also
  Status Clinical Trial Phase
Active, not recruiting NCT00565396 - Effectiveness Study on Fosinopril and/or Losartan in Patients With Chronic Kidney Disease Stage 3 N/A
Recruiting NCT04334707 - Kidney Precision Medicine Project
Recruiting NCT03319888 - Effect of CPAP in the Worsening of Renal Function in Early Stages of Chronic Kidney Disease (CKD) N/A
Recruiting NCT06362759 - A Study to Evaluate TOUR006 in Patients With Chronic Kidney Disease and Elevated Hs-CRP Phase 2
Recruiting NCT02786849 - Neuromuscular Electrical Stimulation During Hemodialysis in Peripheral Muscle Strength and Exercise Capacity N/A
Completed NCT05208788 - Urinary Biomarkers in Paediatric Kidney Transplantation (pKTx)
Completed NCT01767883 - Improving Evidence-Based Primary Care for Chronic Kidney Disease N/A
Terminated NCT02593526 - Diuretic/Cool Dialysate Trial N/A
Unknown status NCT02034149 - The Cost Effectiveness and Evaluation of Disease Management of Chronic Kidney Disease and High Risk Population N/A
Recruiting NCT01834768 - EPLErenone in CsA-Treated Recipients (EpleCsAT): Safety Phase 2
Completed NCT01380717 - Renal and Systemic Vascular Resistance in Chronic Kidney Disease (CKD) Phase 4
Recruiting NCT01364402 - Prevention of Contrast Induced Nephropathy by Erythropoietin Phase 3
Recruiting NCT06238310 - Comparison of Two Different External Clearance Markers - Mannitol and Iohexol for Measuring Glomerular Filtration Rate N/A
Completed NCT03619564 - Chronic Kidney Disease Observational Database - Taiwan
Completed NCT01353417 - Non-interventional-study With Tacrolimus Sandoz© Capsules for Prophylaxis of Renal Graft Rejection N/A
Recruiting NCT03991169 - Oral Iron in Children With Chronic Kidney Disease Phase 4