Pilot Study of Loop Diuretics Among Individuals Receiving Hemodialysis

Status Completed

Clinical Trial Summary

Individuals with kidney failure receiving maintenance hemodialysis (HD) have high mortality rates, driven largely by cardiovascular causes. Volume-related factors are critical, modifiable contributors to cardiovascular complications. Reversing volume overload has been shown to improve blood pressure and cardiac remodeling. Use of loop diuretics may represent a pragmatic, low-cost, and low-burden strategy to improve outcomes in people receiving HD. Lack of data on optimal furosemide dosing, safety, and acceptability are barriers to expanded use. This study investigates whether oral furosemide is safe and effective at increasing urine volume in HD patients.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04622709
Study type	Interventional
Source	University of North Carolina, Chapel Hill
Contact
Status	Completed
Phase	Phase 2
Start date	October 7, 2020
Completion date	June 22, 2021

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05700851` - Immuno-nutrition Supplementation in Haemodialysis	N/A
Recruiting	`NCT02616627` - Association Between DXA Results and the Complications, Clinical Courses and Outcomes in Chronic Dialysis Patients
Completed	`NCT01464190` - A Phase 3 Extension Study to Investigate the Long-term Safety, Tolerability and Efficacy of PA21, a Phosphate Binder in Dialysis Patients	Phase 3
Recruiting	`NCT06040281` - Smart and Fit for Kidney Transplantation	N/A
Active, not recruiting	`NCT03535922` - Evaluation of Routinely Measured Patient-reported Outcomes in Hemodialysis Care	N/A
Completed	`NCT04585607` - Potential Benefits of Expanded Hemodialysis in Prevention of Sarcopenia	Phase 4
Completed	`NCT03182699` - Effect of Etelcalcetide on Cardiac Hypertrophy in Hemodialysis Patients	Phase 4
Completed	`NCT03942744` - The Effect of High-flux Hemodialysis and On-line Hemodiafiltration on Endothelial Function.	N/A
Completed	`NCT04549597` - Study to Evaluate the Use of Tenapanor as Core Therapy in the Treatment of Hyperphosphatemia	Phase 4
Recruiting	`NCT04659525` - Evolocumab Plus Ezetimibe in Haemodialized Statin-intolerant Patients With Hypercholesterolemia	Phase 4
Completed	`NCT04125537` - Pathways Project: Kidney Supportive Care
Recruiting	`NCT03347773` - Oral Nutritional Supplement Intervention Among Hemodialysis Patients With Sarcopenic Obesity	N/A
Recruiting	`NCT04397653` - Evolocumab Plus Ezetimibe in High Risk Haemodialized Statin Intolerant Patients	Phase 4
Active, not recruiting	`NCT03938285` - Effect of Hemodiafiltration Plus MCOs on Uremic Toxins Removal	N/A
Completed	`NCT03525223` - Modulation of Tissue Sodium in Hemodialysis Patients	N/A
Completed	`NCT01324128` - A Phase 3 Study to Investigate the Safety and Efficacy of PA21, a Phosphate Binder, in Dialysis Patients	Phase 3
Not yet recruiting	`NCT04600193` - a Randomized Controlled Trial of the Intake of Organic and Inorganic Phosphate in Peritoneal Dialysis Patients	N/A
Not yet recruiting	`NCT06225544` - Lumasiran in Hyperoxalaemic Patients on Haemodialysis	Phase 2
Recruiting	`NCT05209880` - Advance Care Planning in the Emergency Department	N/A
Enrolling by invitation	`NCT05086185` - Effect of Viscous Fiber on Postprandial Kalemic Response in Hemodialysis Patients