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Intradialytic Resistance Training in Haemodialysis Patients — IRTHEP  

Chronic Kidney Disease Requiring Chronic Dialysis Clinical Trial

Official title:
Effect of Intradialytic Resistance Training on Circulatory miRNA Profile and Muscle Strength in Haemodialysis Patients

Clinical Trial Summary

The study will investigate the effects of an intradialytic resistance training on miRNA´s expression and muscle strength in haemodialysis patients.

Clinical Trial Description

Chronic kidney disease (CKD) is accompanied by distortions of immune functions and acceleration of inflammation processes. Regular exercise has shown great potential for improving the health-related parameters of CKD patients. Moreover, muscle strength is considered to be an important predictor of protein- and energy- wasting, inflammation, quality of life and mortality in CKD patients. The behaviour and individual variability of adaptation to regular, controlled, supervised physical activities in CKD patients are not well defined and understood. The understanding of molecular adaptation mechanisms, represented by the epigenetic impact of exercise on renal specific miRNA´s expression, is necessary for future improvements in clinical practice. Monitoring pro- and anti-inflammation genes activity, their transcription factors and expression of miRNA molecules (influencing the signalling pathways of specific genes) will enable us to draft a new transcription and translation model for exercise-induced adaptation in CKD patients. Additionally, our results will indicate the clinical value of selected markers for the diagnostics and prognostics of disease. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03511924
Study type Interventional
Source Pavol Jozef Safarik University
Contact
Status Completed
Phase N/A
Start date January 11, 2018
Completion date January 31, 2020
View Details
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