Chronic Kidney Disease Clinical Trial
Official title:
Investigating the Immune System in chrONIC Kidney Disease - the SONIC Study.
This study will investigate the function of the immune system in people with chronic kidney disease (CKD) compared to people with normal kidneys. The investigators will use standard vaccines - the seasonal flu vaccine and pneumococcal polysaccharide (Pneumovax) vaccine - to examine how the immune system responds to challenge. All subjects will receive these recommended vaccines as part of routine care. Blood and urine samples will be collected and tested at different time points to look at how the immune response develops to these vaccines and if there are any differences between people with CKD and those without. This will help us understand how CKD affects the function of the immune system.
Compared to the general population, people with CKD are known to get more infections and are
more likely to have complications from them. Protective measures such as vaccinations for
common infections are not as effective in patients with CKD as they are in people with
healthy kidneys. The reasons why this happens are not very clear. It is known that with
increasing age, the body's immune defences are weakened, but it is not yet clear how
different this is in older people with CKD compared to older people with healthy kidneys.
Understanding how CKD affects the body's immune defence to new infections is vital in
helping to prevent severe consequences from infection and make vaccination more effective
for this group of people. This project aims to look at the function of immune cells in CKD
patients and people with normal kidney function, together with their responses to clinically
recommended vaccinations, including Pneumococcus (common pneumonia organism) and the
influenza virus (the flu).
Study participants are invited to receive the clinically recommended seasonal influenza and
pneumococcal polysaccharide vaccines during the seasonal influenza vaccination season
(September - December), mirroring routine care they would receive in the community.
Information on age, gender and pre-existing health problems, together with blood and urine
samples will be collected from CKD patients for comparison with healthy volunteers at the
following timepoints: day of vaccination, day 7 and 28 and 6 months after vaccination.
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Observational Model: Case Control, Time Perspective: Prospective
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