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Effects of T-bet B Cells in Persistent Virus Control After Discontinuance of NAs in CHB Patients

Chronic HBV Infection Clinical Trial

Official title:
Effects of T-bet B Cells in Persistent Virus Control After Discontinuance of NAs in CHB Patients

Clinical Trial Summary

The immune mechanism of the nucleos(t)ide analogs (NAs) in inhibiting HBV replication effectively while having a low sustained virus control rate after drug withdrawal is unclear. B cell immunity and antibody response are the keys to prevent HBV reinfection and keep the virus under control. T-bet+ B, which can be regulated by IL-21, is a newly discovered major effector B cell in protection of pathogens and it is a main subtype of HBsAg-specific B cells. Thus, we suspect that T-bet+ B may play a role in ongoing controlling of the virus after withdraw of NAs in CHB patient. Based on our previous studies on CHB immunity, we use the RNAseq analyse, flow cytometry, and Elispot assay to analyze the frequency, function, and phenotype of B cells in CHB patients with different profiles after withdraw of NAs.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06029634
Study type Observational
Source Changhai Hospital
Contact
Status Completed
Phase
Start date July 1, 2020
Completion date August 20, 2023
View Details
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