| Eligibility |
Inclusion Criteria:
- Diagnosis of chronic hand eczema defined as hand eczema, which has persisted for more
than 3 months or returned twice or more within the last 12 months.
- Disease severity graded as moderate to severe according to IGA (i.e., IGA =2).
- Recent history (within 1 year before the screening visit) of inadequate response to
topical corticosteroid and/or calcineurin inhibitors treatment or topical
corticosteroid treatment being medically inadvisable.
Exclusion Criteria:
- Active atopic dermatitis in regions other than the hands requiring medical treatment.
- Active psoriasis in regions other than the hands requiring medical treatment.
- Clinically significant infection (e.g., impetiginized hand eczema or tinea manum) on
the hands.
- Patients with excessive contact of hands with water (longer than 2 hours at day; or >
20 hands washing at day) that is believed to be a predominant cause of the hand
dermatitis.
- Subjects with known antigen sensitization based on Patch test (with 3 years) that are
unable to reduce contact with the specific antigen(s).
- Subjects chronically and consistently exposed to known-irritant or other substance
known to impact skin barrier will be excluded based on PI judgement
- Systemic treatment with immunosuppressive drugs, immunomodulating drugs, retinoids, or
corticosteroids within 4 weeks prior to baseline.
- Systemic treatment with antibiotics within 4 weeks prior to baseline
- Phototherapy on the hands within 4 weeks prior to baseline.
- Use of topical immunomodulators (e.g., phosphodiesterase-4 (PDE-4) inhibitors,
pimecrolimus, tacrolimus) or topical corticosteroids on the hands within 2 weeks prior
to baseline.
- Use of topical antibiotics on the hands within 2 weeks prior to baseline.
- Change in systemic antihistamine therapy within 2 weeks prior to baseline i.e.,
subjects must not start antihistamine treatment or change the current dosage regime
within 2 weeks prior to baseline.
- Other topicals applied therapy on the hands (except for the use of subject's own
emollients) within 1 week prior to baseline.
- Receipt of any marketed or investigational biologic agents within 6 months or 5
half-lives prior to baseline
- Any disorder which is not stable and in the investigator's opinion could affect the
safety of the subject, influence the findings of the trial, or impede the subject's
ability to complete the trial.
- Participants with clinically significant cytopenia at screening
- Participants with severely impaired liver or kidney function and unstable.
- Participants who have previously received JAK inhibitor therapy, systemic or topical.
- History of any known primary immunodeficiency disorder including a positive human
immunodeficiency virus (HIV), or the subject taking antiretroviral medications.
- Females who are breastfeeding, pregnant, or anticipate becoming pregnant during the
study time frame
- History of skin cancer on hands within 5 years.
- History of recalcitrant warts on hands within 1 year
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