Predictive Biomarkers For Pediatric Chronic Graft-Versus-Host Disease — ABLE-cGVHD  

Chronic Graft vs Host Disease Clinical Trial

Official title: Applying Biomarkers to Long-term Effects in Child and Adolescent Cancer Treatment (ABLE Team) - Predictive Biomarkers For Pediatric Chronic Graft-Versus-Host Disease

Status Active, not recruiting

Clinical Trial Summary

Chronic graft-versus-host disease (cGVHD) can be hard to diagnose, difficult to manage and contributes significantly to morbidity and mortality in hematopoietic stem cell transplantation patients. The research will look into identifying and validating cGVHD biological indicators (=bio-markers) which will be evaluated whether they can predict a future development of the disease. The study hypothesis is that a number of previously reported cGVHD bio-markers, known to be present at the time of cGVHD diagnosis, will also be present at earlier time points, before cGVHD develops. Following validation, the bio-markers will be beneficial for finding those patients who are in higher risk to develop cGVHD. By identifying the higher-risk group, which is more likely to develop cGVHD, a pre-emptive therapy might be applied in order to prevent or reduce the prevalence of the disease.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Bronchiolitis Obliterans Syndrome
• Chronic Graft vs Host Disease
• Graft vs Host Disease

• NCT number: NCT02067832
• Study type: Observational
• Source: University of British Columbia
• Status: Active, not recruiting
• Start date: November 2013
• Completion date: December 2025